1. Sirt4: The Glutamine Gatekeeper
Pablo J. Fernandez-Marcos, Manuel Serrano 
Cancer Cell 
Volume 23, Issue 4, Pages (April 2013)
DOI: /j.ccr
Copyright © 2013 Elsevier Inc. Terms and Conditions

2. Figure 1 SIRT4: The Glutamine Gatekeeper
DNA damage (1) elicits the DDR (2) that, through undefined mechanisms (indicated with a question mark), results in enhanced SIRT4 transcription (3) and higher SIRT4 activity in the mitochondria (4). In turn, SIRT4 inhibits glutamine conversion into αKG by inhibiting glutamate dehydrogenase (GDH) (5). Decreased αKG shuts down the anaplerotic replenishment of the tricarboxylic acid cycle (TCA) (6), which, through mechanisms that remain to be clarified (question mark), result in arrest and DNA repair (7).
Cancer Cell  , DOI: ( /j.ccr )
Copyright © 2013 Elsevier Inc. Terms and Conditions