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Nat. Rev. Rheumatol. doi: /nrrheum

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Presentation on theme: "Nat. Rev. Rheumatol. doi: /nrrheum"— Presentation transcript:

1 Nat. Rev. Rheumatol. doi:10.1038/nrrheum.2016.93
Figure 4 Clock gene deregulation: a functional link between ageing and OA Figure 4 | Clock gene deregulation: a functional link between ageing and OA. During ageing, circadian rhythms deteriorate, leading to increased propensity to obesity, which is a major risk factor for metabolic osteoarthritis (OA). Disrupted circadian rhythms in old age is also associated with altered diurnal patterns and reduced levels of physical activity, further contributing to OA pathogenesis. Age-related decline of local clock functions within the joint can have more direct detrimental effects on the homeostasis of joint tissues. ANS, autonomic nervous system; HPA axis, hypothalamic–pituitary–adrenal axis; HPT axis, hypothalamic–pituitary–thyroid axis. Berenbaum, F. & Meng, Q. –J. (2016) The brain–joint axis in osteoarthritis: nerves, circadian clocks and beyond Nat. Rev. Rheumatol. doi: /nrrheum

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Figure 1 Simplified scheme of TGFβ signalling
Figure 3. Hypothalamic–Pituitary–Adrenal (HPA)-axis functioning moderates crime exposure: regions of significance on X (crime). The lines represent two.

Figure 3. Hypothalamic–Pituitary–Adrenal (HPA)-axis functioning moderates crime exposure: regions of significance on X (crime). The lines represent two.
Figure 3 The induction of anti-DNA antibodies by bacterial DNA

Figure 3 The induction of anti-DNA antibodies by bacterial DNA
Figure 1 Lymphocytes during the disease

Figure 1 Lymphocytes during the disease
Figure 1 Imaging of a painful knee using radiography and MRI

Figure 1 Imaging of a painful knee using radiography and MRI
Figure 3 The adaptive and maladaptive energy matrices

Figure 3 The adaptive and maladaptive energy matrices
Figure 3 Example of how a noncoding regulatory rheumatoid

Figure 3 Example of how a noncoding regulatory rheumatoid
Figure 3 Connexins in cartilage

Figure 3 Connexins in cartilage
Figure 3 Metabolism in homeostatic chondrocytes

Figure 3 Metabolism in homeostatic chondrocytes
Figure 2 Representative MSI data obtained from human joints

Figure 2 Representative MSI data obtained from human joints
Figure 1 Rheumatoid arthritis development over time in relation to the level of inflammation Figure 1 | Rheumatoid arthritis development over time in relation.

Figure 1 Rheumatoid arthritis development over time in relation to the level of inflammation Figure 1 | Rheumatoid arthritis development over time in relation.
Nat. Rev. Rheumatol. doi: /nrrheum

Nat. Rev. Rheumatol. doi: /nrrheum
Figure 4 Interactions between adipose, the microbiome and kidney

Figure 4 Interactions between adipose, the microbiome and kidney
Figure 1 Grip strength across the lifecourse

Figure 1 Grip strength across the lifecourse
Figure 3 Neuromuscular exercise

Figure 3 Neuromuscular exercise
Nat. Rev. Rheumatol. doi: /nrrheum

Nat. Rev. Rheumatol. doi: /nrrheum
Figure 1 Factors underlying metabolic alterations in osteoarthritis

Figure 1 Factors underlying metabolic alterations in osteoarthritis
Nat. Rev. Rheumatol. doi: /nrrheum

Nat. Rev. Rheumatol. doi: /nrrheum
Figure 1 Induction of immune tolerance

Figure 1 Induction of immune tolerance
Figure 2 Risk factors for sarcopenia

Figure 2 Risk factors for sarcopenia

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