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Volume 112, Issue 8, Pages (April 2017)

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1 Volume 112, Issue 8, Pages 1535-1538 (April 2017)
Increased Tissue Stiffness in Tumors from Mice with Neurofibromatosis-1 Optic Glioma  Christopher Walter, Lindsey Crawford, Melinda Lai, Joseph A. Toonen, Yuan Pan, Shelly Sakiyama-Elbert, David H. Gutmann, Amit Pathak  Biophysical Journal  Volume 112, Issue 8, Pages (April 2017) DOI: /j.bpj Copyright © 2017 Biophysical Society Terms and Conditions

2 Figure 1 Increased stiffness of glioma-bearing optic nerves at the chiasm. (A) Diagram describing the two regions where AFM measurements were taken, the chiasm and the optic nerve (≥1 mm proximal to the chiasm). (B) Average tissue stiffness obtained using AFM. Error bars represent the mean ± SE. N > 34; ∗p < To see this figure in color, go online. Biophysical Journal  , DOI: ( /j.bpj ) Copyright © 2017 Biophysical Society Terms and Conditions

3 Figure 2 Glioma-bearing optic nerves have decreased MMP-2 expression in the chiasm (A), but not in the unaffected proximal optic nerve segment (B), mirroring the effects shown with AFM. ∗p < Error bars represent the mean ± SE. Scale bars represent 100 μm. To see this figure in color, go online. Biophysical Journal  , DOI: ( /j.bpj ) Copyright © 2017 Biophysical Society Terms and Conditions

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