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Transplantation of hematopoietic stem cells and long-term survival for primary immunodeficiencies in Europe: Entering a new century, do we do better? 

Published byDomenico Mattei Modified over 5 years ago

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Presentation on theme: "Transplantation of hematopoietic stem cells and long-term survival for primary immunodeficiencies in Europe: Entering a new century, do we do better? "— Presentation transcript:

1 Transplantation of hematopoietic stem cells and long-term survival for primary immunodeficiencies in Europe: Entering a new century, do we do better?  Andrew R. Gennery, MD, Mary A. Slatter, MD, Laure Grandin, MSc, Pierre Taupin, MD, Andrew J. Cant, FRCP, Paul Veys, FRCP, Persis J. Amrolia, FRCP, H. Bobby Gaspar, PhD, E. Graham Davies, FRCPCH, Wilhelm Friedrich, PhD, Manfred Hoenig, MD, Luigi D. Notarangelo, MD, Evelina Mazzolari, MD, Fulvio Porta, MD, Robbert G.M. Bredius, PhD, Arjen C. Lankester, PhD, Nico M. Wulffraat, PhD, Reinhard Seger, MD, Tayfun Güngör, MD, Anders Fasth, PhD, Petr Sedlacek, PhD, Benedicte Neven, MD, Stephane Blanche, MD, Alain Fischer, PhD, Marina Cavazzana-Calvo, PhD, Paul Landais, PhD  Journal of Allergy and Clinical Immunology  Volume 126, Issue 3, Pages e11 (September 2010) DOI: /j.jaci Copyright © 2010 American Academy of Allergy, Asthma & Immunology Terms and Conditions

2 Fig 1 Cumulative probability of survival in patients with SCID after HSCT according to the period in which transplanted, donor source (related or URD), and HLA matching. MMR, Mismatched related; RGI, related genoidentical; RPI, related phenoidentical. Journal of Allergy and Clinical Immunology  , e11DOI: ( /j.jaci ) Copyright © 2010 American Academy of Allergy, Asthma & Immunology Terms and Conditions

3 Fig 2 Cumulative probability of survival in patients with T-B- or T- B+ SCID after HSCT through all periods. Journal of Allergy and Clinical Immunology  , e11DOI: ( /j.jaci ) Copyright © 2010 American Academy of Allergy, Asthma & Immunology Terms and Conditions

4 Fig 3 Cumulative probability of survival in patients with non-SCID PID after HSCT according to the period in which transplanted, donor source (related or URD), and HLA matching and type of immunodeficiency through all periods. MMR, Mismatched related; RGI, related genoidentical; RPI, related phenoidentical. Journal of Allergy and Clinical Immunology  , e11DOI: ( /j.jaci ) Copyright © 2010 American Academy of Allergy, Asthma & Immunology Terms and Conditions

5 Cumulative probability of survival in patients with SCID after HSCT according to year at grafting in HLA-mismatched SCID. Journal of Allergy and Clinical Immunology  , e11DOI: ( /j.jaci ) Copyright © 2010 American Academy of Allergy, Asthma & Immunology Terms and Conditions

6 Cumulative probability of survival in patients with SCID after HSCT according to donor source (related or URD) and HLA matching for the period 2000 to MMR, Mismatched related; RGI, related genoidentical; RPI, related phenoidentical. Journal of Allergy and Clinical Immunology  , e11DOI: ( /j.jaci ) Copyright © 2010 American Academy of Allergy, Asthma & Immunology Terms and Conditions

7 Cumulative probability of survival in patients with SCID after HSCT according to age at transplantation through all periods. Journal of Allergy and Clinical Immunology  , e11DOI: ( /j.jaci ) Copyright © 2010 American Academy of Allergy, Asthma & Immunology Terms and Conditions

8 Cumulative probability of survival in patients with non-SCID PID after HSCT according to donor source (related or URD) and HLA matching for the period 2000 to MMR, Mismatched related; RGI, related genoidentical; RPI, related phenoidentical. Journal of Allergy and Clinical Immunology  , e11DOI: ( /j.jaci ) Copyright © 2010 American Academy of Allergy, Asthma & Immunology Terms and Conditions

9 Cumulative probability of survival in patients with non-SCID PID after HSCT according to type of T-cell deficiency for the period 1995 to 2005. Journal of Allergy and Clinical Immunology  , e11DOI: ( /j.jaci ) Copyright © 2010 American Academy of Allergy, Asthma & Immunology Terms and Conditions

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