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Claus Bachert, MD, PhD, Luo Zhang, MD, Phillippe Gevaert, MD 

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Presentation on theme: "Claus Bachert, MD, PhD, Luo Zhang, MD, Phillippe Gevaert, MD "— Presentation transcript:

1 Current and future treatment options for adult chronic rhinosinusitis: Focus on nasal polyposis 
Claus Bachert, MD, PhD, Luo Zhang, MD, Phillippe Gevaert, MD  Journal of Allergy and Clinical Immunology  Volume 136, Issue 6, Pages (December 2015) DOI: /j.jaci Copyright © 2015 American Academy of Allergy, Asthma & Immunology Terms and Conditions

2 Fig 1 Prevalence of CRS in different regions of the world.
Journal of Allergy and Clinical Immunology  , DOI: ( /j.jaci ) Copyright © 2015 American Academy of Allergy, Asthma & Immunology Terms and Conditions

3 Fig 2 Inflammatory subtypes and associations with presence of nasal polyps, asthma, and recurrence. This graph is based on an analysis defining clusters based on cytokine expression, IgE levels, and mediators (P. Tomassen, et al, 2015). TH2-biased inflammation is associated with the presence of polyps, asthma comorbidity, and the likelihood of recurrence. MPO, Myeloperoxidase; SE-IgE, IgE to staphylococcal enterotoxins. Journal of Allergy and Clinical Immunology  , DOI: ( /j.jaci ) Copyright © 2015 American Academy of Allergy, Asthma & Immunology Terms and Conditions

4 Fig 3 CT scans of the sinuses before and 3 months after omalizumab therapy. Journal of Allergy and Clinical Immunology  , DOI: ( /j.jaci ) Copyright © 2015 American Academy of Allergy, Asthma & Immunology Terms and Conditions

5 Fig 4 Principles of dupilumab therapy. By binding to IL-4 receptor α (IL-4Rα), pathways for IL-4 and IL-13 are blocked. IL-13Rα, IL-13 receptor α; IRS1/2, insulin receptor substrate 1/2; JAK, Janus kinase; PI3K, phosphoinositide 3-kinase; STAT, signal transducer and activator of transcription. Journal of Allergy and Clinical Immunology  , DOI: ( /j.jaci ) Copyright © 2015 American Academy of Allergy, Asthma & Immunology Terms and Conditions

6 Fig 5 Role of GATA-3 and principles of DNAzyme therapy.
Used with permission from Krug et al.53 Journal of Allergy and Clinical Immunology  , DOI: ( /j.jaci ) Copyright © 2015 American Academy of Allergy, Asthma & Immunology Terms and Conditions

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