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Constanze S. Rayhrer, Timothy D. Edmisten, Gerald A. Cephas, Curtis G

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Presentation on theme: "Constanze S. Rayhrer, Timothy D. Edmisten, Gerald A. Cephas, Curtis G"— Presentation transcript:

1 Nitric Oxide Potentiates Acute Lung Injury in an Isolated Rabbit Lung Model 
Constanze S. Rayhrer, Timothy D. Edmisten, Gerald A. Cephas, Curtis G. Tribble, Irving L. Kron, Jeffrey S. Young  The Annals of Thoracic Surgery  Volume 65, Issue 4, Pages (April 1998) DOI: /S (98)

2 Fig. 1 Experimental apparatus used. (ABG = arterial blood gas measurement site; NO = nitric oxide; OA = oleic acid; SNP = sodium nitroprusside; vent = ventilator.) The Annals of Thoracic Surgery  , DOI: ( /S (98) )

3 Fig. 2 Pulmonary artery pressure (PAP) measurements (mm Hg) at 20, 40, and 60 minutes after initiation of oleic acid (OA) infusion or saline infusion. (NOC = nitric oxide control; NORx = nitric oxide treatment.) The Annals of Thoracic Surgery  , DOI: ( /S (98) )

4 Fig. 3 Changes in dynamic airway compliance (CPL) at 20, 40, and 60 minutes after initiation of saline or oleic acid (OA) infusion. (NOC = nitric oxide control; NORx = nitric oxide treatment.) The Annals of Thoracic Surgery  , DOI: ( /S (98) )

5 Fig. 4 Changes in pulmonary vascular resistance (PVR; dyne · s/cm5) at 20, 40, and 60 minutes after initiation of oleic acid (OA) or saline infusion. (NOC = nitric oxide control; NORx = nitric oxide treatment.) The Annals of Thoracic Surgery  , DOI: ( /S (98) )

6 Fig. 5 Changes in arteriovenous O2 difference (AVO2; mm Hg) at 20, 40, and 60 minutes after initiation of saline or oleic acid (OA) infusion. (NOC = nitric oxide control; NORx = nitric oxide treatment.) The Annals of Thoracic Surgery  , DOI: ( /S (98) )

7 Fig. 6 Wet-to-dry weight ratios for each experimental group. (NOC = nitric oxide control; NORx = nitric oxide treatment; OAC = oleic acid control; SC = saline control; ∗p < 0.05 versus OAC.) The Annals of Thoracic Surgery  , DOI: ( /S (98) )

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