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Early and Late Extensive Chronic Graft-versus-Host Disease in Children Is Characterized by Different Th1/Th2 Cytokine Profiles: Findings of the Children's.

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Presentation on theme: "Early and Late Extensive Chronic Graft-versus-Host Disease in Children Is Characterized by Different Th1/Th2 Cytokine Profiles: Findings of the Children's."— Presentation transcript:

1 Early and Late Extensive Chronic Graft-versus-Host Disease in Children Is Characterized by Different Th1/Th2 Cytokine Profiles: Findings of the Children's Oncology Group Study ASCT0031  Jacob Rozmus, Kirk R. Schultz, Kristin Wynne, Amina Kariminia, Preeti Satyanarayana, Mark Krailo, Stephan A. Grupp, Andrew L. Gilman, Frederick D. Goldman  Biology of Blood and Marrow Transplantation  Volume 17, Issue 12, Pages (December 2011) DOI: /j.bbmt Copyright © 2011 American Society for Blood and Marrow Transplantation Terms and Conditions

2 Figure 1 (A) IFN-γ mRNA production at early and late time points in controls and patients with cGVHD after PI stimulation for 18 hours. (B) IFN-γ mRNA production at early and late time points in controls and patients with cGVHD after anti-CD3 mAb stimulation for 18 hours. (C) IL-2 mRNA production at early and late time points in controls and patients with cGVHD after PI stimulation for 18 hours. (D) IL-2 mRNA production at early and late time points in controls and patients with cGVHD after anti-CD3 mAb stimulation for 18 hours. (E) IL-4 mRNA production at early and late time points in controls and patients with cGVHD after PI stimulation for 18 hours. (F) IL-4 mRNA production at early and late time points in controls and patients with cGVHD after anti-CD3 mAb stimulation for 18 hours. (G) IL-10 mRNA production at early and late time points in controls and patients with cGVHD after anti-CD3 mAb stimulation for 18 hours. Biology of Blood and Marrow Transplantation  , DOI: ( /j.bbmt ) Copyright © 2011 American Society for Blood and Marrow Transplantation Terms and Conditions

3 Figure 2 (A) ROC curve analysis of IFN-γ mRNA production after PI stimulation for predicting the absence of early cGVHD. (B) ROC curve analysis of IL-2 mRNA production after anti-CD3 stimulation for predicting the absence of late cGVHD. (C) ROC curve analysis of IL-4 mRNA production after anti-CD3 stimulation for predicting the absence of late cGVHD. Biology of Blood and Marrow Transplantation  , DOI: ( /j.bbmt ) Copyright © 2011 American Society for Blood and Marrow Transplantation Terms and Conditions

4 Figure 3 (A) Foxp3 production at early and late time points in controls and patients with cGVHD in unstimulated samples. (B) Foxp3 production at early and late time points in controls and patients with cGVHD after anti-CD3 mAb stimulation for 18 hours. Biology of Blood and Marrow Transplantation  , DOI: ( /j.bbmt ) Copyright © 2011 American Society for Blood and Marrow Transplantation Terms and Conditions


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