1. Cat with Fever and Depression
Dennis B. DeNicola, DVM, PhD, DACVP
Chief Veterinary Educator
IDEXX Laboratories

2. “Whispers” Adult Domestic Shorthair Cat Intact male
Presented with clinical history of recent depression

3. “Whispers” – Adult DSH cat
WBC = K/L HIGH ( – )
LYM = K/L LOW ( – )
MONO = K/L HIGH ( – )
NEU = K/L HIGH ( – )
EOS = K/L HIGH ( – )
BASO = K/L ( – )
%LYM = 1.3 %
%MONO = 2.9 %
%NEU = 91.0 %
%EOS = 4.7 %
%BASO = 0.1 %
HCT * 12.5 % LOW ( 30.0 – )
RBC * 2.78 M/L LOW ( – )
HGB = 5.0 g/dL LOW ( – )
RETIC = 76.3 K/L
%RETIC = 2.7 %
MCV * 45.1 fL ( – )
RDW = 24.9 % HIGH ( – )
MCHC = --- g/dL ( – )
MCH = pg HIGH ( – )
PLT = 299 K/L ( 175 – 600 )
MPV = fL
PCT = 0.7 %
PDW = 20.5 %
MCHC out of reportable range

4. “Whispers” – Adult DSH cat
Erythron
HCT * % LOW ( – )
RBC * M/L LOW ( – )
HGB = 5.0 g/dL LOW ( – )
RETIC = 76.3 K/L
%RETIC = 2.7 %
MCV * fL HIGH ( – )
RDW = 24.9 % HIGH ( – )
MCHC = --- g/dL HIGH ( – )
MCH = pg HIGH (12.50 – )

5. “Whispers” – Adult DSH cat
Erythron
HCT * % LOW ( – )
RBC * M/L LOW ( – )
HGB = 5.0 g/dL LOW ( – )

6. “Whispers” – Adult DSH cat
Erythron
HCT * % LOW ( – )
RBC * M/L LOW ( – )
HGB = 5.0 g/dL LOW ( – )
Anemia
Moderately severe

7. “Whispers” – Adult DSH cat
Erythron
HCT * % LOW ( – )
RBC * M/L LOW ( – )
HGB = 5.0 g/dL LOW ( – )
RETIC = 76.3 K/L
%RETIC = 2.7 %
Anemia
Moderately severe

8. “Whispers” – Adult DSH cat
Erythron
HCT * % LOW ( – )
RBC * M/L LOW ( – )
HGB = 5.0 g/dL LOW ( – )
RETIC = 76.3 K/L
%RETIC = 2.7 %
Anemia
Moderately severe, regenerative

9. “Whispers” – Adult DSH cat
Erythron
HCT * 12.5 % LOW ( – )
RBC * 2.78 M/L LOW ( – )
HGB = 5.0 g/dL LOW ( – )
RETIC = 76.3 K/L
%RETIC = 2.7 %
MCV * 45.1 fL HIGH ( – )
RDW = 24.9 % HIGH ( – )
MCHC = --- g/dL HIGH ( – )
MCH = pg HIGH (12.50 – )
Anemia
Moderately severe, regenerative

10. “Whispers” – Adult DSH cat
Erythron
HCT * 12.5 % LOW ( – )
RBC * 2.78 M/L LOW ( – )
HGB = 5.0 g/dL LOW ( – )
RETIC = 76.3 K/L
%RETIC = 2.7 %
MCV * 45.1 fL HIGH ( – )
RDW = 24.9 % HIGH ( – )
MCHC = --- g/dL HIGH ( – )
MCH = pg HIGH (12.50 – )
Anemia
Moderately severe, regenerative, normocytic and moderate anisocytosis

11. Erythron – Data Interpretation
Anemia
Moderately severe
Normocytic (Normal MCV)
Regenerative (Reticulocyte Count)
Moderate anisocytosis (RDW)

12. Erythron – Blood Film

13. Erythron – Blood Film

14. Erythron – Blood Film

15. Saline Agglutination Test
Saline Solution
Agglutination
Rouleaux

16. Erythron – Blood Film

17. Erythron – Blood Film

18. Erythron – Blood Film Interpretation
Anemia
Moderately severe
Regenerative
Polychromasia
Anisocytosis

19. Erythron – Blood Film Interpretation
Anemia
Moderately severe
Regenerative
Polychromasia
Anisocytosis
Potential immune-mediated

20. Erythron – Blood Film Interpretation
Anemia
Moderately severe
Regenerative
Polychromasia
Anisocytosis
Potential immune-mediated
Possible Haemobartonellosis

21. “Whispers” – Adult DSH cat
Leukon
WBC = K/L HIGH ( – )
LYM = 0.39 K/L LOW ( – )
MONO = 0.90 K/L HIGH ( – )
NEU = K/L HIGH ( – )
EOS = 1.46 K/L HIGH ( – )
BASO = 0.04 K/L ( – )
%LYM = 1.3 %
%MONO = 2.9 %
%NEU = 91.0 %
%EOS = 4.7 %
%BASO = 0.04 %

22. “Whispers” – Adult DSH cat
Leukon
WBC = K/L HIGH ( – )

23. “Whispers” – Adult DSH cat
Leukon
WBC = K/L HIGH ( – )
Leukocytosis
Moderate

24. “Whispers” – Adult DSH cat
Leukon
WBC = K/L HIGH ( – )
LYM = 0.39 K/L LOW ( – )
MONO = 0.90 K/L HIGH ( – )
NEU = K/L HIGH ( – )
EOS = 1.46 K/L HIGH ( – )
BASO = 0.04 K/L ( – )
%LYM = 1.3 %
%MONO = 2.9 %
%NEU = 91.0 %
%EOS = 4.7 %
%BASO = 0.04 %

25. “Whispers” – Adult DSH cat
Leukon
WBC = K/L HIGH ( – )
LYM = 0.39 K/L LOW ( – )
MONO = 0.90 K/L HIGH ( – )
NEU = K/L HIGH ( – )
EOS = 1.46 K/L HIGH ( – )
BASO = 0.04 K/L ( – )
%LYM = 1.3 %
%MONO = 2.9 %
%NEU = 91.0 %
%EOS = 4.7 %
%BASO = 0.04 %
Leukocytosis
Moderate
Neutrophilia
Lymphopenia
Monocytosis
Eosinophilia

26. Leukon – Blood Film

27. Leukon – Blood Film

28. Leukogram Interpretation
Moderate leukocytosis
Increases in neutrophils, monocytes and eosinophils
Decrease in lymphocytes

29. Leukogram Interpretation
Moderate leukocytosis
Increases in neutrophils, monocytes and eosinophils
Decrease in lymphocytes
Inflammation with evidence of superimposed glucocorticoid influence (“stress”) and possible tissue demand for macrophages (monocytosis)

30. “Whispers” – Adult DSH cat
WBC = K/L HIGH ( – )
LYM = K/L LOW ( – )
MONO = K/L HIGH ( – )
NEU = K/L HIGH ( – )
EOS = K/L HIGH ( – )
BASO = K/L ( – )
%LYM = 1.3 %
%MONO = 2.9 %
%NEU = 91.0 %
%EOS = 4.7 %
%BASO = 0.1 %
HCT * 12.5 % LOW ( 30.0 – )
RBC * 2.78 M/L LOW ( – )
HGB = 5.0 g/dL LOW ( – )
RETIC = 76.3 K/L
%RETIC = 2.7 %
MCV * 45.1 fL ( – )
RDW = 24.9 % HIGH ( – )
MCHC = --- g/dL ( – )
MCH = pg HIGH ( – )
PLT = 299 K/L ( 175 – 600 )
MPV = fL
PCT = 0.7 %
PDW = 20.5 %
MCHC out of reportable range