1. Potency of menthol depends on L9´ residue size.
Potency of menthol depends on L9´ residue size. A1–B2, Plot of IC40 for (−)-menthol versus residue length (A1) or residue volume (B1) and plot of IC30 for (+)-menthol versus residue length (A2) or residue volume (B2). C1, Fitting the IC40 values for (−)-menthol against the reduced AA index. C2, Fitting the IC30 values for (+)-menthol against the reduced AA index. R2 values in C1 and C2 for each parameter are indicated in extended Figures 7-1 and 7-2. D, Concentration–response relationship for (−)-menthol on (α4[L9´I])3(β2)2 and (α4[L9´O-Me-Thr])3(β2)2 nAChRs. Structures of the two amino acids are shown to the left along with their end-to-end length; n = 7–18 oocytes.
Brandon J. Henderson et al. eNeuro 2018;5:ENEURO
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