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Silencing the Transcriptome's Dark Matter: Mechanisms for Suppressing Translation of Intergenic Transcripts  Kellie S. Bickel, David R. Morris  Molecular.

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Presentation on theme: "Silencing the Transcriptome's Dark Matter: Mechanisms for Suppressing Translation of Intergenic Transcripts  Kellie S. Bickel, David R. Morris  Molecular."— Presentation transcript:

1 Silencing the Transcriptome's Dark Matter: Mechanisms for Suppressing Translation of Intergenic Transcripts  Kellie S. Bickel, David R. Morris  Molecular Cell  Volume 22, Issue 3, Pages (May 2006) DOI: /j.molcel Copyright © 2006 Elsevier Inc. Terms and Conditions

2 Figure 1 Like the Dark Matter of the Universe, the Dark Matter of the Eukaryotic Transcriptome Is Becoming Better Defined Several safeguards exist within eukaryotic cells that prevent adventitious expression of protein from transcripts resulting from spurious RNA Pol II initiation while simultaneously providing cells with valuable potential to evolve new functional genomic loci. In this figure, areas marked with X's highlight mechanisms that result in transcript degradation and the area with light gray designates translational silencing. Molecular Cell  , DOI: ( /j.molcel ) Copyright © 2006 Elsevier Inc. Terms and Conditions

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