1. Nucleotides and Nucleic acids By Prof. Dr. Adel M. Awadallah
Organic chemistry for medicine and biology students
Chem 2311
Chapter 18
Nucleotides and Nucleic acids
By Prof. Dr.
Adel M. Awadallah
Islamic University of Gaza

2. Nucleic acids (DNA & RNA) are linear, chain macromolecules that were first isolated from cell nuclei.
They have a backbone of sugar molecules, each with a base attached, connected by phosphate links.

4. Nucleosides
N-Glycosides

5. A nucleoside is an N-Glycoside
A nucleoside is an N-Glycoside. The pyrimidine or purine base is connected to the anomeric carbon of the sugar.
The pyrimidines are connected at N-1 and the purines are connected at N-9.

6. Nucleosides are water soluble
Nucleosides are water soluble. They can be hydrolyzed by aqueous acid or enzymes to the sugar and heterocyclic base

10. The primary structure of DNA