1. Mannan binding lectin: a two-faced regulator of renal allograft injury? 
Jeffrey Damman, Marc A. Seelen 
Kidney International 
Volume 83, Issue 2, Pages (February 2013)
DOI: /ki
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2. Figure 1
Hypothetical mechanisms of renal allograft protection and injury by complement dependent (Bay et al.) and complement independent mechanisms (Berger et al.). In healthy subjects, normal distribution of high and low order MBL is found in the circulation. In recipients undergoing dialysis, uremia is thought to significantly decrease functional, high order MBL oligomers and increase non-functional, low order oligomers. When renal allografts experience moderate renal injury, fragments from dying cells can be appropriately cleared from the circulation by the opsonizing properties of MBL. Under circumstances of severe allograft injury, the renal tubular epithelium becomes accessible for MBL, causing direct cytotoxic injury by low ór high order MBL oligomers, independent from complement activation.
Kidney International  , DOI: ( /ki )
Copyright © 2013 International Society of Nephrology Terms and Conditions