1. Interferon free treatment
Hepatocellular carcinoma prevention
Reduced side effects
Sustained viral response
Virologic cure for hepatitis C
Interferon-free treatment, due to the development of direct-acting antiviral agents, represented a key-point regarding the therapy of hepatitis C and the prevention of hepatocellular carcinoma.
Introduction
Case report
» female patient, 58 y.o.
» hepatic cirrhosis , Fibro test score = 0.88, F4
» treatment regimen: Dasabuvir 250 mg - 1cpx 2/a day, Ombitasvir/ Paritaprevir/ Ritonavir 12,5 mg/ 75 mg/ 50 mg – 2 cp/a day, 3 months
» double valve replacement with mechanical prostheses→ oral anticoagulation
Treatment initiation
802 UI/ml
Week 12 of treatment
Undetectable
12 weeks following the end of the treatment
Results and discussion
After 1 year
Portal vein thrombosis (INR: 4,7-5,9)
Hepatocelullar carcinoma
Conclusions
Interferon-free treatment → possible cause of portal vein thrombosis
Hepatocelullar carcinoma → procoagulant status→ portal vein thrombosis
Interferon-free treatment – risk factor for the portal vein thrombosis?
Ruxandra Lazăr¹,Luminița Confederat¹, Irina Gîrleanu1,²
¹ “Grigore T. Popa” University of Medicine and Pharmacy, Faculty of Medicine- Iași, Romania
² Institute of Gastroenterology and Hepatology – Iași, Romania