1. Multiple genotypes circulating in the NIS region
WHO Euro Regional Reference Laboratory for Measles/Rubella,
G.N.Gabrichevsky Research Institute for Epidemiology and Microbiology, Moscow, Russia

2. Number of measles cases 2015
Measles incidence, NIS,2015
Country
Number of measles cases 2015
Genotyping
data avail.
Azerbaijan
Armenia 33 +
Belarus 2
Moldova
Kazakhstan
2341
Kyrgyzstan
21343
Russia
843
Tajikistan 3 ?
Turkmenistan
Ukraine
105
Uzbekistan 22
Measles incidence, cases/1 mln. of pop.
0; < 1; …5; …15; >100; > 3000

3. Measles incidence and genotypes, Russia, 2014
4711 cases, 32,4/ ,
D8 – 301 (10 gen. variants)
D4 Az - 11
D4 MVs/Manchester.GBR/10.09 – 4 B
H1 – 2
G3 – 1
112 imp. cases 29 countries
Number of cases
Week
Number of strains
D8 Chui
first isolation
Week
Genotype

4. Measles incidence and genotypes, Russia, 2015
843 cases, 0,58/ ,
D8 – 205 (7 gen. lineages) D8Chui - 115
H1 – 15 (2 gen. lineages)
B3 - 1
Number of cases
Week
Number of strains
D8 RoK
last isolation
D8 Chui
last isolation
Week
Genotype

5. Measles genotypes, NIS, 2015 Kyrgyzstan 21343 rep. cases
MVs/South Kazakhstan.KAZ/5.15/
MVi/Villupuram.IND/03.07/ Named strain
MVs/South Khazakhstan.KAZ/5.15/3 5733
Kyrgyzstan rep. cases
D8 MVs/Chui.KGZ/53.14/ Named strain
Uzbekistan 22 cases
D8 (2 seq. var. linked to Kaz. outbreak, + 1 linked to Kyrgyzstan?)
Armenia 33 cases
D8 MVi/Villupuram.IND/03.07/ Named strain
MVs/South Khazakhstan.KAZ/5.15/2 5732
Kazakhstan 2341 cases
D8 (5 seq, var. 3 gen. lin.) B3
MVs/South Kazakhstan.KAZ/5.15/
MVs/South Kazakhstan.KAZ/4.15/ 5731
MVs/South Khazakhstan.KAZ/3.15/2 5730
MVs/Shymkent City.KAZ/11.15/
MVs/North Khazakhstan.KAZ/11.15/ 5743
MVs/Akmola.KAZ/9.15/ 5740
MVs/Akmola.KAZ/7.15/ 5738
MVs/Tashkent.UZB/7.15 Imp. Kazakhstan/
MVs/Tashkent.UZB/5.15Imp. Kazakhstan /
MVs/Aragats.ARM/35.15/2 5920
MVs/Aragats.ARM/35.15/ 5919
MVs/Chui.KGZ/2.15/ 5582
MVs/Bishkek.KGZ/1.15/2 5557
MVs/Bishkek.KGZ/2.15/ 5572
MVs/Bishkek.KGZ/2.15/2 5579
MVs/Bishkek.KGZ/2.15/3 5580
MVs/Talas.KGZ/4.15/ 5594
MVs/Talas.KGZ/4.15/2 5596_
MVs/Talas.KGZ/6.15/ 5600
MVs/Talas.KGZ/6.15/2 5602
MVs/Tashkent.UZB/30.15/ 5849
MVs/Chui.KGZ/53.14/ Named strain
MVs/Akmola.KAZ/8.15/ 5739
MVs/Republic of Komi.RUS/35.13/[D8] 3884 Named strain 99
MVs/North Kazakhstan.KAZ/18.15/ 5745 99
MVs/Frankfurt Main.DEU/17.11/ Named strain
MVs/Tashkent.UZB/30.15/2 Imp. Kazakhstan
MVs/Tashkent.UZB/30.15/3 Imp. Kazakhstan 99
MVs/Pretoria.ZAF/19.09/
MVs/Petropavlovsk.KAZ/22.15/2
MVs/South Khazakhstan.KAZ/3.15/ 5729
MVs/Sohar.OMN/23.12/
Manchester.UNK/30/94_D8
Edmonstonwt.USA/54_A
NewYork.USA/94_B3
Ibandan.Nie/97/1 B3 99 97
MVs/Kansas.USA/1.12/2 Named strain Imp Ethiopia 99
MVs/North Khazakhstan.KAZ/17.15/ 5

6. Kyrgyzstan and linked сases in Russia
MVs/Tyumen.RUS/4.15/ Imp. Kyrgyzstan
Russia 2015
Kyrgyzstan – linked
cases
MVs/Tyumen.RUS/11.15/ Imp. Kyrgyzstan
MVs/Stavropol.RUS/19.15/ Imp. Kyrgyzstan
MVs/Republic of Dagestan.RUS/20.15/ Imp. Kyrgyzstan
MVs/Ufa.RUS/16.15/ Imp. Kyrgyzstan
MVs/Novosibirsk.RUS/19.15/ Imp. Kyrgyzstan
MVs/Moscow.RUS/17.15/ Imp. Kyrgyzstan
MVs/Moscow.RUS/16.15/8/ Imp. Kyrgyzstan
MVs/Moscow.RUS/16.15/5 Imp. Kyrgyzstan
MVs/Moscow.RUS/16.15/3 Imp. Kyrgyzstan
MVs/Moscow.RUS/15.15/4 Imp. Kyrgyzstan
MVs/Moscow.RUS/12.15/6 Imp. Kyrgyzstan
MVs/Moscow.RUS/10.15/2 Imp. Kyrgyzstan
MVs/Krasnoyarsk.RUS/11.15/ Imp. Kyrgyzstan
MVs/Irkutsk.RUS/25.15/3 Imp. Kyrgyzstan
MVs/Irkutsk.RUS/25.15/2 Imp. Kyrgyzstan
MVs/Ulan-Ude.RUS/23.15/ Imp. Kyrgyzstan
MVs/Ivanovo.RUS/8.15/ Imp. Kyrgyzstan
MVs/Talas.KGZ/6.15/2 5602
Kyrgyzstan
MVs/Talas.KGZ/6.15/ 5600
MVs/Talas.KGZ/4.15/2 5596_
MVs/Talas.KGZ/4.15/ 5594
MVs/Bishkek.KGZ/2.15/3 5580
MVs/Bishkek.KGZ/2.15/2 5579
MVs/Bishkek.KGZ/2.15/ 5572
MVs/Bishkek.KGZ/1.15/2 5557
MVs/Chui.KGZ/2.15/ 5582
MVs/Chui.KGZ/53.14/ Named strain
2014
100
MVs/Chelyabinsk.RUS/53.14/ Imp. Kyrgyzstan
MVs/Bishkek.KGZ/53.14/ 5553
MVs/Chui.KGZ/53.14/2 5558
MVi/Villupuram.IND/03.07/ Named strain
MVs/Chui.KGZ/23.14/ Imp. Kazakhstan
MVs/St.Petersburg.RUS/19.15/ Imp. Kyrgyzstan
Manchester.UNK/30/94_D8
Edmonstonwt.USA/54_A 5

7. Russia, measles 2016 Number of cases Region Jan Feb Mar Apr Total
MVs/Republic of Buriatia.RUS/7.16/2/
Region
Jan
Feb
Mar
Apr
Total
Moscow 1 2
R. of Tatarstan
Ingush Republic
North Osetia
R. Of Chechnya 4 5
Rostov on Don
Irkutsk
Stavropol
R. of Buryatia
Russia 9 22
MVs/Liaoning.CHN/13.14/2
MVs/Republic of Buriatia.RUS/7.16/
MVs/Irkutsk.RUS/21.16/ 6130
MVs/Irkutsk.RUS/20.16/2/ 6128
MVs/Irkutsk.RUS/20.16/ Linked to China 91
MVs/Hong Kong.CHN/49.12/ H1 Named strain
MVs/Republic of Buriatia.RUS/15.16/ 6082
MVs/Republic of Buriatia.RUS/18.16/2/ 6106 99
MVs/Ulaanbaatar.MNG/44.15/
MVs/Republic of Buriatia.RUS/18.16/ 6104 99
MVs/Shandong.CHN/13.15/18
MVs/Hong Kong.CHN/42.11/ Named strain
Hunan.CHN/93/7_H1
Edmonstonwt.USA/54_A 91
MVs/Republic of Tatarstan.RUS/4.16/ Imp. India
MVs/Faridabad.IND/22.14/
Manchester.UNK/30/94_D8 99
MVs/Perm.RUS/3.16/ Imp. Kazakhstan
MVi/Villupuram.IND/03.07 Named strain / 99
MVs/Ingush Republic.RUS/17.16/ 6119 80
MVs/Frankfurt Main.DEU/17.11/ Named strain
MVs/Lipetsk.RUS/22.16/ Linked to R.of Chechnya 99
MVs/Moscow.RUS/17.16/ 6085
MVs/Rostov-on-Don.RUS/17.16/ 6114
MVs/Rostov-on-Don.RUS/17.16/2/ 6116
MVs/Rostov-on-Don.RUS/19.16/ 6117 5

8. Summary
Measles incidence linked to virus importation that results in different scenarios (from sporadic cases to nation-wide outbreaks);
Multiple introduction of the virus + “pockets of susceptible” (unvaccinated adults and young infants, Roma pop., religious groups) sustain prolonged transmission;
Predominance of different D8 measles lineages with origin outside of the NIS region and simultaneous transmission of many different sequence variants of the virus observed.
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9. Thank you!

10. “Extra slides”

11. Rubella incidence, NIS,2015 - 2016
Country
Number of cases 2015
Genotyping
data avail.
Azerbaijan
Armenia*
Belarus 1 ?
Moldova
Kazakhstan 2
Kyrgyzstan
101
Russia 25 +
Tajikistan
Turkmenistan
Ukraine
248
Uzbekistan
Number of cases, Russia 2016 (Jan – Apr)
Region
Jan
Feb
Mar
Apr
Total
Archangelsk 2
St. Petersburg 1
Moscow 4
Yaroslavl 7 3 9 23
Orel
Kursk
Krasnodar
Stavropol
Russia 8 6 12 35

12. Rubella genotypes, Russia, 2014 - 2016
RVs/Yaroslavl.RUS/13.16/ 6066
RVs/Yaroslavl.RUS/16.16/ 6099
Outbake 28 cases Oct May 2016
Unknown source
RVs/Yaroslavl.RUS/12.16/ 6069
RVs/Yaroslavl.RUS/11.16/ 6062
RVs/Yaroslavl.RUS/03.16/ 6009
Strains 2015
RVs/Orel.RUS/53.15/ 6002
RVs/Zongo.COD/13.13/
100
RVs/Kinshasa.COD/23.12/
Strains 2016 97
RVs/Novgorod.RUS/13.15/ 5375
Outbreak 6 cases African students Feb – Mar 2015
Unknown source 88
RVs/Novgorod.RUS/13.15/2 5377
RVs/Moscow.RUS/22.16/ 6132 95
RVs/Florida.USA/04.16/ Imp.India
RVs/Astrakhan.RUS/10.14/ 4z175/1
RVi/Kedah.MYS/05.14/
RVi/Kelantan.MYS/05.14/ 99
RVs/HongKong.CHN/49.08 99
RVs/Astrakhan.RUS/03.14/ 4859
RVs/Astrakhan.RUS/16.14/ 4z995
RVs/Astrakhan.RUS/16.14/2 4z998
RVs/Astrakhan.RUS/01.15/CRS 5027
Rvi/Seattle.WA.USA/16.00[2B]
RVi/TelAviv.ISR/68[2B]
RVi/BEL/63[1a]
RVi/Dezhou.CHN/02[1E]
100
RVi/North Carolina.USA/15.11/[1E] Imp Indonezia 97 99
RVs/Moscow.RUS/17.14/ 4z830 97
RVs/Samara.RUS/27.14/ 4N829 5

13. Summary
Rubella in Russia is not endemic, very limited data for other countries.
Исправить слайд для результатов 2012г.