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Bar graphs show the proportion of patients classified by the number of brain lesions in bins of 10 lesions (A), and the distribution of brain lesions categorized by the location (PVWM, DWM, SCWM, DGM, BS, cerebellum) (B) for rater 1. Bar graphs show the proportion of patients classified by the number of brain lesions in bins of 10 lesions (A), and the distribution of brain lesions categorized by the location (PVWM, DWM, SCWM, DGM, BS, cerebellum) (B) for rater 1. A total of 911 brain lesions in 79 patients with NMOSD and 1659 brain lesions in 87 patients with MS are identified. A, The proportion of patients is significantly different between NMOSD and MS (P = .015; weighted κ value, 0.92). More patients with NMOSD have no brain lesions of ≥3 mm, and a tendency for patients with MS to have more brain lesions than those with NMOSD is found. B, The distribution of lesions categorized by location is significantly different between NMOSD and MS (P < .001). DWM lesions (68%) are more frequent than PVWM lesions (17%) in NMOSD, whereas the difference in the frequencies of lesions in PVWM (41%) and DWM (42%) is small in MS. H. Tatekawa et al. AJNR Am J Neuroradiol 2018;39: ©2018 by American Society of Neuroradiology
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