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Circulating microRNAs as potential biomarkers for endometriosis
SiHyun Cho, M.D., Levent Mutlu, M.D., Olga Grechukhina, M.D., Hugh S. Taylor, M.D. Fertility and Sterility Volume 103, Issue 5, Pages e1 (May 2015) DOI: /j.fertnstert Copyright © 2015 American Society for Reproductive Medicine Terms and Conditions
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Figure 1 MicroRNAs differentially expressed in the sera of endometriosis patients and controls. (A–D) The expression levels of let-7b and mir-135a were statistically significantly lower in patients with endometriosis than in controls, and let-7d and 7f showed a trend toward decreased expression. Data are represented by box-and-whisker plots. Boxes indicate the 25th and 75th percentiles, with a solid line within the box showing the median value. Fertility and Sterility , e1DOI: ( /j.fertnstert ) Copyright © 2015 American Society for Reproductive Medicine Terms and Conditions
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Figure 2 Expression levels of miRNA in serum from endometriosis patients and controls according to the menstrual cycle. During the proliferative phase, (A) let-7b, (B) let-7c, (C) let-7d, and (D) let-7e were statistically significantly down-regulated in endometriosis patients compared with controls. (E) The expression levels of let-7f showed a trend toward down-regulation. (F) During the secretory phase, mir-135a was statistically significantly down-regulated in patients with endometriosis compared with controls. Data are represented by box-and-whisker plots. Boxes indicate the 25th and 75th percentiles, with a solid line within the box showing the median value. Fertility and Sterility , e1DOI: ( /j.fertnstert ) Copyright © 2015 American Society for Reproductive Medicine Terms and Conditions
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Figure 3 Receiver operating characteristic (ROC) curves of different miRNAs during the proliferative phase. (A) Let-7d showed the highest AUC of (B) When the combination of the serum miRNA expression levels during the proliferative phase was used with a logistic regression model, the combination of serum let-7b, let-7d, and let-7f showed the highest AUC value of Fertility and Sterility , e1DOI: ( /j.fertnstert ) Copyright © 2015 American Society for Reproductive Medicine Terms and Conditions
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Supplemental Figure 1 Correlations between let-7b expression levels and serum CA-125 levels. A significant negative correlation was noted (r = −0.333). Fertility and Sterility , e1DOI: ( /j.fertnstert ) Copyright © 2015 American Society for Reproductive Medicine Terms and Conditions
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