Presentation is loading. Please wait.

Presentation is loading. Please wait.

Discovery of a small molecule inhibitor of the Wnt pathway (SM04690) as a potential disease modifying treatment for knee osteoarthritis  J.D. Hood, V.

Published byJayson Wiggins Modified over 5 years ago

Similar presentations

Presentation on theme: "Discovery of a small molecule inhibitor of the Wnt pathway (SM04690) as a potential disease modifying treatment for knee osteoarthritis  J.D. Hood, V."— Presentation transcript:

1 Discovery of a small molecule inhibitor of the Wnt pathway (SM04690) as a potential disease modifying treatment for knee osteoarthritis  J.D. Hood, V. Deshmukh, C. Barroga, Y. Hu  Osteoarthritis and Cartilage  Volume 24, Pages S14-S15 (April 2016) DOI: /j.joca Copyright © Terms and Conditions

2 Figure 1 SM04690 induces chondrogenesis in human mesenchymal stem cells. Osteoarthritis and Cartilage  , S14-S15DOI: ( /j.joca ) Copyright © Terms and Conditions

3 Figure 2 SM04690 increases cartilage thickness relative to control in rat instability model. Note:Arrows in Figure 2 designate articular cartilage. Osteoarthritis and Cartilage  , S14-S15DOI: ( /j.joca ) Copyright © Terms and Conditions

Download ppt "Discovery of a small molecule inhibitor of the Wnt pathway (SM04690) as a potential disease modifying treatment for knee osteoarthritis  J.D. Hood, V."

Similar presentations

Full-thickness cartilage defects repaired by human induced pluripotent stem cells (IPSCS)-derived mesenchymal stem cells and plga scaffolds D. Shi, X.

Full-thickness cartilage defects repaired by human induced pluripotent stem cells (IPSCS)-derived mesenchymal stem cells and plga scaffolds D. Shi, X.
Synergistic effects of progranulin and low intensity pulsed ultrasound on chondrocyte differentiation, migration and metabolism  S.M. Uddin, B. Richbourgh,

Synergistic effects of progranulin and low intensity pulsed ultrasound on chondrocyte differentiation, migration and metabolism  S.M. Uddin, B. Richbourgh,
Full-thickness cartilage defects repaired by human induced pluripotent stem cells (IPSCS)-derived mesenchymal stem cells and plga scaffolds  D. Shi, X.

Full-thickness cartilage defects repaired by human induced pluripotent stem cells (IPSCS)-derived mesenchymal stem cells and plga scaffolds  D. Shi, X.
Immunomodulatory effect of mesenchymal stem cells following intra-articular injection in a model of osteoarthritis: a potential role for apoptosis  P.

Immunomodulatory effect of mesenchymal stem cells following intra-articular injection in a model of osteoarthritis: a potential role for apoptosis  P.
A. Bhave, M. Mont, M. Chugthai, R. Starr  Osteoarthritis and Cartilage 

A. Bhave, M. Mont, M. Chugthai, R. Starr  Osteoarthritis and Cartilage 
R. Takeuchi, H. Ishikawa, T. Kuniya, A. Nakazawa 

R. Takeuchi, H. Ishikawa, T. Kuniya, A. Nakazawa 
S. Gavard  Osteoarthritis and Cartilage 

S. Gavard  Osteoarthritis and Cartilage 
Gene expression profiling for confirmation of effects of DNA polymeric molecules on in vitro arthritis model  H.-J. Kim, A. Baek, M. Kim, S.-R. Cho  Osteoarthritis.

Gene expression profiling for confirmation of effects of DNA polymeric molecules on in vitro arthritis model  H.-J. Kim, A. Baek, M. Kim, S.-R. Cho  Osteoarthritis.
In vitro cell surface markers are insufficient to identify in vivo/in situ multipotent synovial mesenchymal stem cells isolated from normal or osteoarthritic.

In vitro cell surface markers are insufficient to identify in vivo/in situ multipotent synovial mesenchymal stem cells isolated from normal or osteoarthritic.
Isotropic three-dimensional T2 mapping of knee cartilage with T2-prepared segmented gradient ECHO at 3T  R. Colotti, P. Omoumi, R.B. van Heeswijk  Osteoarthritis.

Isotropic three-dimensional T2 mapping of knee cartilage with T2-prepared segmented gradient ECHO at 3T  R. Colotti, P. Omoumi, R.B. van Heeswijk  Osteoarthritis.
Prospective economic evaluation of the costs for medications and nutraceuticals in knee osteoarthritis  M. Chung, N. Zhao, J.B. Wong, C. Wang  Osteoarthritis.

Prospective economic evaluation of the costs for medications and nutraceuticals in knee osteoarthritis  M. Chung, N. Zhao, J.B. Wong, C. Wang  Osteoarthritis.
Does a yoga-strengthening program for women with knee osteoarthritis have an effect on gait patterns? An investigation with principal components analysis 

Does a yoga-strengthening program for women with knee osteoarthritis have an effect on gait patterns? An investigation with principal components analysis 
Human synovial fluid derived mesenchymal stem cells expanded under low oxygen conditions and in a serum-free environment exhibit enhanced lineage-specific.

Human synovial fluid derived mesenchymal stem cells expanded under low oxygen conditions and in a serum-free environment exhibit enhanced lineage-specific.
Role of endothelin-1 in endochondral ossification and osteoarthritis

Role of endothelin-1 in endochondral ossification and osteoarthritis
Automatic cartilage segmentation and measurement for diagnosis of OA using 3D box and Gaussian filters  X. Cui, S. Li, M. Yu, H. Kim, K.-S. Kwack, B.-H.

Automatic cartilage segmentation and measurement for diagnosis of OA using 3D box and Gaussian filters  X. Cui, S. Li, M. Yu, H. Kim, K.-S. Kwack, B.-H.
Mineralization of meniscal enthesis in osteoarthritic knees

Mineralization of meniscal enthesis in osteoarthritic knees
Effect of self assembled peptide-mesenchymal stem cell complex on delaying the progression of osteoarthritis  S. Kim, S. Lee, Y. Jung, J. Kim, S. Kim 

Effect of self assembled peptide-mesenchymal stem cell complex on delaying the progression of osteoarthritis  S. Kim, S. Lee, Y. Jung, J. Kim, S. Kim 
Quantitative T1ρ, T2 and T2* mapping of articular cartilage changes in a rat model of osteoarthritis using in vivo high-resolution magnetic resonance.

Quantitative T1ρ, T2 and T2* mapping of articular cartilage changes in a rat model of osteoarthritis using in vivo high-resolution magnetic resonance.
G. Venne, S. Pang, Y. Tse, R. Ellis  Osteoarthritis and Cartilage 

G. Venne, S. Pang, Y. Tse, R. Ellis  Osteoarthritis and Cartilage 
Comparison of the Usefulness of Laser-induced Photoacoustic Measurement & Magnetic Resonance Imaging (T2 Mapping, Diffusion Tensor Imaging) for Assessing.

Comparison of the Usefulness of Laser-induced Photoacoustic Measurement & Magnetic Resonance Imaging (T2 Mapping, Diffusion Tensor Imaging) for Assessing.

Similar presentations

Ads by Google