1. Tumor microenvironment features that affect metastatic progression.
Tumor microenvironment features that affect metastatic progression. Features of the tumor microenvironment are thought to play a role in facilitating or promoting tumorigenic behavior. These features include adhesive signals from extracellular matrix components such as collagen and fibrin; soluble signals like growth factors and cytokines; extracellular matrix mechanical features including stiffness and local tension or compression; and cell–cell interactions with intra- and extra-tumoral stromal cells. Adapted with permission from Hubbell (2008) and Lutolf and Hubbell (2005).
Jacob L. Albritton, and Jordan S. Miller Dis. Model. Mech. 2017;10:3-14
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