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Airway remodeling and inflammation in competitive swimmers training in indoor chlorinated swimming pools  Valérie Bougault, PhD, Lionel Loubaki, MSc,

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Presentation on theme: "Airway remodeling and inflammation in competitive swimmers training in indoor chlorinated swimming pools  Valérie Bougault, PhD, Lionel Loubaki, MSc,"— Presentation transcript:

1 Airway remodeling and inflammation in competitive swimmers training in indoor chlorinated swimming pools  Valérie Bougault, PhD, Lionel Loubaki, MSc, Philippe Joubert, MD, PhD, Julie Turmel, PhD, Christian Couture, MSc, MD, FRCPC, Michel Laviolette, MD, Jamila Chakir, PhD, Louis-Philippe Boulet, MD, FRCPC, FCCP  Journal of Allergy and Clinical Immunology  Volume 129, Issue 2, Pages e1 (February 2012) DOI: /j.jaci Copyright © 2011 American Academy of Allergy, Asthma & Immunology Terms and Conditions

2 Fig 1 Quantification of inflammatory cells (number of cells per square millimeter of connective tissue) in bronchial biopsy specimens from controls, swimmers, and asthmatic subjects. Horizontal bar represents median value. Subjects with methacholine AHR are represented with a full symbol, and those without AHR are represented with an empty symbol. Subjects without allergies, either swimmers or asthmatic subjects, are represented with a triangle in their respective group. ∗P < .05 entire swimmer group versus controls. †P < .05 asthmatic subjects versus controls. ‡P < .05 entire swimmer group versus asthmatic subjects. Journal of Allergy and Clinical Immunology  , e1DOI: ( /j.jaci ) Copyright © 2011 American Academy of Allergy, Asthma & Immunology Terms and Conditions

3 Fig 2 Representative bronchial tissue from a nonatopic swimmer without methacholine AHR. A, Tenascin deposition under the basement membrane. B, Collagen III deposition C, Collagen I deposition. D, Mucin 5 immunostaining. Journal of Allergy and Clinical Immunology  , e1DOI: ( /j.jaci ) Copyright © 2011 American Academy of Allergy, Asthma & Immunology Terms and Conditions

4 Fig 3 Mucin 5A (percentage staining intensity per square millimeter of connective tissue) staining in controls, swimmers, and asthmatic subjects. Horizontal bar represents median value. Subjects with methacholine AHR are represented with a full symbol, and those without AHR are represented with an empty symbol. Subjects without allergies, either swimmers or asthmatic subjects, are represented with a triangle in their respective group. ∗P < .01 entire swimmer group versus controls. ‡P < .05 entire swimmer group versus asthmatic subjects. Journal of Allergy and Clinical Immunology  , e1DOI: ( /j.jaci ) Copyright © 2011 American Academy of Allergy, Asthma & Immunology Terms and Conditions

5 Fig 4 Thickness of tenascin immunoreactive band and collagen I and collagen III deposition in subepithelial basement membrane zone in controls, swimmers, and asthmatic subjects. Horizontal bar represents median value. Subjects with allergies, either swimmers or asthmatic subjects, are represented with a triangle in their respective group. Subjects with methacholine AHR are represented with a full symbol, and those without AHR are represented with an empty symbol. Subjects without allergies, either swimmers or asthmatic subjects, are represented with a triangle in their respective group. ∗P < .05 entire swimmer group versus controls. ∗∗P < .005 entire swimmer group versus controls. †P < .05 asthmatic subjects versus controls. Journal of Allergy and Clinical Immunology  , e1DOI: ( /j.jaci ) Copyright © 2011 American Academy of Allergy, Asthma & Immunology Terms and Conditions

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