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Human cerebral microcirculation and oxygen saturation during propofol-induced reduction of bispectral index†  K.U. Klein, K. Fukui, P. Schramm, A. Stadie,

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Presentation on theme: "Human cerebral microcirculation and oxygen saturation during propofol-induced reduction of bispectral index†  K.U. Klein, K. Fukui, P. Schramm, A. Stadie,"— Presentation transcript:

1 Human cerebral microcirculation and oxygen saturation during propofol-induced reduction of bispectral index†  K.U. Klein, K. Fukui, P. Schramm, A. Stadie, G. Fischer, C. Werner, J. Oertel, K. Engelhard  British Journal of Anaesthesia  Volume 107, Issue 5, Pages (November 2011) DOI: /bja/aer227 Copyright © 2011 The Author(s) Terms and Conditions

2 Fig 1 Frontal BIS of the non-operated hemisphere in dependency of i.v. propofol dosage (mg kg−1 h−1). British Journal of Anaesthesia  , DOI: ( /bja/aer227) Copyright © 2011 The Author(s) Terms and Conditions

3 Fig 2 Regional capillary venous oxygen saturation (srvO2) (a), CBF (rvCBF) (b), and Hb amount (rvHb) (c) in 2 mm (grey matter) and 8 mm (white matter) cerebral tissue at normal propofol dosage [5.1 (2.3) mg kg−1 h−1, BIS 40 (9)] vs higher propofol dosage [7.8 (2.1) mg kg−1 h−1, BIS 21 (7)]; srvO2, regional capillary venous cerebral oxygen saturation; rvCBF, regional capillary venous cerebral blood flow; rvHb, regional capillary venous cerebral Hb concentration. n = 15 patients. British Journal of Anaesthesia  , DOI: ( /bja/aer227) Copyright © 2011 The Author(s) Terms and Conditions

4 Fig 3 Arteriovenous difference in oxygen content (avDO2) (a) and approximated cerebral metabolic rate of oxygen (aCMRO2) (b) in 2 mm (grey matter) and 8 mm (white matter) cerebral tissue at normal propofol dosage [5.1 (2.3) mg kg−1 h−1, BIS 40 (9)] vs higher propofol dosage [7.8 (2.1) mg kg−1 h−1, BIS 21 (7)]; avDO2, regional arteriovenous difference in oxygen content; aCMRO2, regional approximated cerebral metabolic rate of oxygen. n = 15 patients. British Journal of Anaesthesia  , DOI: ( /bja/aer227) Copyright © 2011 The Author(s) Terms and Conditions


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