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Storage of radial artery grafts in blood increases vessel reactivity to vasoconstrictors in vitro  James Tatoulis, Guang-Chi Jiang, PhD, James D Moffatt,

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Presentation on theme: "Storage of radial artery grafts in blood increases vessel reactivity to vasoconstrictors in vitro  James Tatoulis, Guang-Chi Jiang, PhD, James D Moffatt,"— Presentation transcript:

1 Storage of radial artery grafts in blood increases vessel reactivity to vasoconstrictors in vitro 
James Tatoulis, Guang-Chi Jiang, PhD, James D Moffatt, PhD, Thomas M Cocks, PhD  The Annals of Thoracic Surgery  Volume 68, Issue 6, Pages (December 1999) DOI: /S (99)

2 Fig 1 Cumulative contraction curves to the vasoconstrictor substances U46619 (a thromboxane A2 analogue), angiotensin II (AII), noradrenaline (NA), serotonin (5-HT) and potassium chloride (KCl) in rings of radial artery used either immediately after harvest (A) or stored in heparinized blood containing 1% papaverine (B, stored). On each graph, points represent the mean ± the standard error of the mean (4 to 7 experiments). All values are expressed as percentages of the maximum contraction to 125 mM KCl-containing Krebs’ solution (see Table 1 for details of pEC50 and Fmax values). The Annals of Thoracic Surgery  , DOI: ( /S (99) )

3 Fig 2 Cumulative relaxation curves to the endothelium-dependent vasodilator acetylcholine in rings of radial artery used either immediately after harvest (control), or following storage in heparinized blood containing 1% papaverine (stored). Points of each curve represent the mean ± the standard error of the mean (4 to 6 experiments), expressed as percentages of the maximum relaxation to the endothelium-independent vasodilator sodium nitroprusside (SNP, 10 μM). The Annals of Thoracic Surgery  , DOI: ( /S (99) )


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