1. Cyclodextrin polysulphates repress IL-1 and promote the accumulation of chondrocyte extracellular matrix 
P. Verdonk, M.D., J. Wang, M.D., S. Groeneboer, B.Sc., C. Broddelez, D. Elewaut, M.D., E.M. Veys, M.D., G. Verbruggen, M.D. 
Osteoarthritis and Cartilage 
Volume 13, Issue 10, Pages (October 2005)
DOI: /j.joca
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2. Fig. 1
A: Synthesis of CDPSs – schematic representation. B: Cellulose acetate electrophoresis of the sulphated polysaccharides. +: Positive pool; →: start; lane 1: hyaluronan, chondroitin sulphate; lane 2: chondroitin sulphate; lane 3; CPS; lane 4: α-CDPS; lane 5: β-CDPS; lane 6: γ-CDPS; lane 7: xylosan polysulphate.
Osteoarthritis and Cartilage  , DOI: ( /j.joca )
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3. Fig. 2
Percentage changes in 35S-incorporation in aggrecan induced by different concentrations of CDPSs. Dots represent mean values of experiments in triplicate. Bars represent median values. ○: effect of α-cyclodextrins, : effect of β-cyclodextrins, ●: effect of γ-cyclodextrins.
Osteoarthritis and Cartilage  , DOI: ( /j.joca )
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4. Fig. 3
Fluorescence intensity patterns of chondrocytes labelled with FITC–mAb directed against intracellular IL-1α and -β, CAM aggrecan, type II collagen and fibronectin illustrate how small changes in IL-1 producing cells, induce vast increases in the accumulation of CAM products. Isotype control curves and fluorescence intensity patterns of 5.0μg/ml of β-cyclodextrin (bCD)-treated and control cells are shown for each of the tested variables. Donor: M18; Ordinate: events (number of cells) studied; abscissa: fluorescence intensity.
Osteoarthritis and Cartilage  , DOI: ( /j.joca )
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5. Fig. 4
IL-6 release by normal (NO), normal TNFα-primed (NO+TNF), and OA chondrocytes. : control cultures, : β-cyclodextrin-treated cells. Experiments were done in triplicate. Mean values±1 SD are shown.
Osteoarthritis and Cartilage  , DOI: ( /j.joca )
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