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Signal transducer and activator of transcription 5 tyrosine phosphorylation for the diagnosis and monitoring of patients with severe combined immunodeficiency 

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Presentation on theme: "Signal transducer and activator of transcription 5 tyrosine phosphorylation for the diagnosis and monitoring of patients with severe combined immunodeficiency "— Presentation transcript:

1 Signal transducer and activator of transcription 5 tyrosine phosphorylation for the diagnosis and monitoring of patients with severe combined immunodeficiency  Denise Walshe, FIBMS, CSci, H. Bobby Gaspar, MD, PhD, Adrian J. Thrasher, MD, PhD, Catherine M. Cale, MD, PhD, Kimberly C. Gilmour, PhD  Journal of Allergy and Clinical Immunology  Volume 123, Issue 2, Pages (February 2009) DOI: /j.jaci Copyright © 2009 American Academy of Allergy, Asthma & Immunology Terms and Conditions

2 Fig 1 Tyrosine-phosphorylated STAT5 is detected in a control subject but not in a γc-deficient patient. A, γc Staining. B, EMSA showing cells stimulated with IL-2. C, STAT5 ptyr staining on unstimulated (black) and IL-2–stimulated (gray) cells. C, Control; P, patient with γc SCID (patient 1); Co/Po, control/patient plus specific oligonucleotide; PMF, patient with maternal fetal engraftment (patient 14). D, Graph showing the mean and SD percentage change in STAT5 ptyr in control subjects and subjects with combined immunodeficiencies/SCIDs, γc/JAK3 SCIDs (samples with maternal-fetal engraftment not included), and γc SCIDs after therapy. Journal of Allergy and Clinical Immunology  , DOI: ( /j.jaci ) Copyright © 2009 American Academy of Allergy, Asthma & Immunology Terms and Conditions

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