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Overexpression of IL-12, IL-23 or their receptors is implicated

Published byLisa Eriksson Modified over 5 years ago

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Presentation on theme: "Overexpression of IL-12, IL-23 or their receptors is implicated"— Presentation transcript:

1 Overexpression of IL-12, IL-23 or their receptors is implicated
in the development of several autoimmune diseases IL-23 IL-12 IL-23 IL-12 IL-23 IL-12 IFNγ Naive T cell IFNγ Th1 IFNγ Th1 IL-17F IL-22 Naive T cell IL-17F IL-22 Naive T cell IFNγ Th17 Th17 Naive T cell IFNγ IFNγ IL-17A IL-17A Autoimmune disorders eg psoriasis

2 Ustekinumab blocks binding of IL-12 and IL-23 to their receptors,
thereby reducing the autoimmune response IL-12 IL-23 IL-23 IL-12 IL-23 IL-12 IFNγ Naive T cell Th1 IL-17F IL-22 Naive T cell Naive T cell IFNγ Th17 Naive T cell IFNγ IL-17A Autoimmune disorders eg psoriasis

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