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WHAT IS THE COMMON CAUSE OF THIS LESION

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Presentation on theme: "WHAT IS THE COMMON CAUSE OF THIS LESION"— Presentation transcript:

1 WHAT IS THE COMMON CAUSE OF THIS LESION
                                     Grossly, the cerebral infarction at the upper left here demonstrates liquefactive necrosis. Grossly, the cerebral infarction at the upper left here demonstrates liquefactive necrosis. WHAT IS THE COMMON CAUSE OF THIS LESION

2 THIS IS FROM ESOPHAGUS, IDENTIFY THE LESION
Metaplasia of the normal esophageal squamous mucosa has occurred here, with the appearance of gastric type columnar mucosa Metaplasia of the normal esophageal squamous mucosa has occurred here, with the appearance of gastric type columnar mucosa THIS IS FROM ESOPHAGUS, IDENTIFY THE LESION

3 Cardiac hypertrophy IDENTIFY THE LESION

4 WHAT TYPE OF NECROSIS IS THIS?
It is a wedge-shaped pale area of coagulative necrosis (infarction) in the renal cortex of the kidney is a wedge-shaped pale area of coagulative necrosis (infarction) in the renal cortex of the kidney WHAT TYPE OF NECROSIS IS THIS?

5 WHAT IS THE COMMON CAUSE OF THIS TYPE OF NECROSIS
Coagulative necrosis, adrenal infarction Coagulative necrosis is most commonly caused by hypoxic conditions that do not involve severe trauma, toxins or an acute or chronic immune response. The lack of oxygen causes cell death in a localised area which is perfused by blood vessels failing to deliver primarily oxygen, but also other important nutrients.                                      Coagulative necrosis is most commonly caused by hypoxic conditions that do not involve severe trauma, toxins or an acute or chronic immune response. The lack of oxygen causes cell death in a localised area which is perfused by blood vessels failing to deliver primarily oxygen, but also other important nutrients. It is important to note that while ischemia in most tissues of the body will cause coagulative necrosis, in the central nervous system ischemia causes liquefactive necrosis as there is very little structural framework in the brain tissue. WHAT IS THE COMMON CAUSE OF THIS TYPE OF NECROSIS

6 DRY GANGRENE                                      IDENTIFY THIS LESION

7 NAME THE CELL POINTED BY ARROW.
                                     Giant cells are a "committee" of epithelioid macrophages. Seen here are two Langhans type giant cells in which the nuclei are lined up around the periphery of the cell. Additional pink epithelioid macrophages compose most of the rest of the granuloma Giant cells are a "committee" of epithelioid macrophages. Seen here are two Langhans type giant cells in which the nuclei are lined up around the periphery of the cell. Additional pink epithelioid macrophages compose most of the rest of the granuloma NAME THE CELL POINTED BY ARROW.

8 WHAT TYPE OF NECROSIS IS THIS?
Seen here in a hilar lymph node is a granuloma. Granulomas due to infectious agents such as mycobacteria are often described as "caseating" when they have prominent caseous necrosis                                      WHAT TYPE OF NECROSIS IS THIS?

9 LABEL THIS IMAGE --------------- --------------
Gangrenous small intestine A                                      Don’t kno  The dark red to grey infarcted bowel contrasts with the pale pink normal bowel at the bottom B LABEL THIS IMAGE

10 Normal Pyknosis Karyorrhexis Karyolysis
Label the nuclear changes seen during necrosis

11 FAT NECROSIS Caused by:
Release of activated pancreatic lipases into the substance of the pancreas & peritonial cavity Identify the type of necrosis Name the common cause


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