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Levels of circulating IL-33 and eosinophil cationic protein in patients with hypereosinophilia or pulmonary eosinophilia  Hak-Ryul Kim, MD, Chang-Duk.

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Presentation on theme: "Levels of circulating IL-33 and eosinophil cationic protein in patients with hypereosinophilia or pulmonary eosinophilia  Hak-Ryul Kim, MD, Chang-Duk."— Presentation transcript:

1 Levels of circulating IL-33 and eosinophil cationic protein in patients with hypereosinophilia or pulmonary eosinophilia  Hak-Ryul Kim, MD, Chang-Duk Jun, PhD, Young-Jin Lee, MD, Sei-Hoon Yang, MD, Eun-Taik Jeong, MD, Seok-Don Park, MD, Do-Sim Park, MD, PhD  Journal of Allergy and Clinical Immunology  Volume 126, Issue 4, Pages e6 (October 2010) DOI: /j.jaci Copyright © 2010 American Academy of Allergy, Asthma & Immunology Terms and Conditions

2 Fig 1 Levels of circulating IL-33, sST2, and eosinophilia-related markers in patients with hypereosinophilia or pulmonary eosinophilia and healthy controls. Each box indicates the median. Horizontal lines indicate interquartile ranges. The blue line indicates 500 eosinophils/μL blood. ∗P < .05; ∗∗P < .01. Journal of Allergy and Clinical Immunology  , e6DOI: ( /j.jaci ) Copyright © 2010 American Academy of Allergy, Asthma & Immunology Terms and Conditions

3 Fig 2 Changes in levels of IL-33, sST2, CRP, and eosinophilia-related markers after symptom improvement in patients with idiopathic acute eosinophilic pneumonia. First P values, comparison of the first 3 days with 5 to 10 days after the admission date; second P values, comparison of the first 3 days with 15 to 30 days after the admission date. ∗P < .05. Journal of Allergy and Clinical Immunology  , e6DOI: ( /j.jaci ) Copyright © 2010 American Academy of Allergy, Asthma & Immunology Terms and Conditions

4 Comparison of diagnostic accuracies of IL-33, sST2, and eosinophilia-related markers for identifying PE using ROC curves. Numbers in parentheses indicate diagnostic accuracies (area under the ROC curves) for total PE (A) or PE with a normal number of blood eosinophils (B; less than 500 per μL). ∗Controls (N = 194) were selected from subjects with less than 350 eosinophils/μL blood. Journal of Allergy and Clinical Immunology  , e6DOI: ( /j.jaci ) Copyright © 2010 American Academy of Allergy, Asthma & Immunology Terms and Conditions

5 Changes in the levels of IL-33, sST2, and eosinophilia-related markers after normalization of blood eosinophil numbers in patients with hypereosinophilia. ∗P < .05; ∗∗P < .01. HE, State of hypereosinophilia (>1500/ μL); NR, state of normal eosinophil numbers (<350/μL). Group A, Patients with drug reaction; Group B, patients with immune-mediated disease (2 with skin disease, 2 with vasculitis, 2 with eosinophilic gastroenteritis, and 1 with asthma); Group C, patients with solid tumors. Journal of Allergy and Clinical Immunology  , e6DOI: ( /j.jaci ) Copyright © 2010 American Academy of Allergy, Asthma & Immunology Terms and Conditions

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