1. Relationships between H. pylori, inflammation, and acid secretion.
Relationships between H. pylori, inflammation, and acid secretion. H. pylori infection can reduce acid secretion and increase inflammation via multiple intermediates. Increased production of IL-1β and TNF-α from inflammatory cells inhibits acid secretion from parietal cells. Acid secretion is also inhibited by repression of H+K+ ATPase α-subunit promoter activity, in addition to VacA-induced proteolysis of ezrin.
Lydia E. Wroblewski et al. Clin. Microbiol. Rev. 2010; doi: /CMR