1. Are perioperative therapeutic doses of statins associated with postoperative pain and opioid consumption after hip surgery under spinal anaesthesia? 
W. Saasouh, S. Leung, H.O. Yilmaz, O. Koyuncu, J. You, N.M. Zimmerman, K. Ruetzler, A. Turan 
British Journal of Anaesthesia 
Volume 119, Issue 4, Pages (October 2017)
DOI: /bja/aex232
Copyright © 2017 The Author(s) Terms and Conditions

2. Fig 1
Flow chart.
British Journal of Anaesthesia  , DOI: ( /bja/aex232)
Copyright © 2017 The Author(s) Terms and Conditions

3. Fig 2
Plot of absolute standardized difference (ASD) between statin users and non-users on covariables before and after inverse probability of treatment weighting. Absolute standardized difference is absolute difference in means or proportions divided by the pooled standard deviation. An ASD of 0.8 represents large differences between the two groups while an ASD of 0.2 represents small differences. Any covariables with an ASD > 0.2 were considered to be imbalanced.
British Journal of Anaesthesia  , DOI: ( /bja/aex232)
Copyright © 2017 The Author(s) Terms and Conditions

4. Fig 3
Boxplots of time-weighted average (TWA) of pain score over time and total opioid consumption during initial 72 h after surgery (on the logarithm scale). The first quartile, median, and third quartile comprise the boxes; whiskers extend to the most extreme observations within 1.5 times the interquartile range of the first and third quartiles, respectively.
British Journal of Anaesthesia  , DOI: ( /bja/aex232)
Copyright © 2017 The Author(s) Terms and Conditions

5. Fig 4
Plot of difference in means of pain score and ratio of geometric means of total opioid consumption during initial 72 h after surgery. The difference in means of pain score was estimated using a mixed-effects model with repeated measures. The ratio of geometric means of total opioid consumption was estimated using a multivariable linear regression model. In both analyses, each observation was weighted by the inverse probability of treatment weighting to control for potential confounding. The statin and non-statin patients were equivalent on opioid consumption and on pain score, as the estimated confidence interval lies within the pre-specified equivalence region (i.e.   plus or minus 1 for pain score and plus or minus 15% for opioid consumption).
British Journal of Anaesthesia  , DOI: ( /bja/aex232)
Copyright © 2017 The Author(s) Terms and Conditions