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David L. Smith, MD, J. Graham Smith, MD, Song W. Wong, MD, Richard D

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Presentation on theme: "David L. Smith, MD, J. Graham Smith, MD, Song W. Wong, MD, Richard D"— Presentation transcript:

1 Netherton's syndrome: A syndrome of elevated IgE and characteristic skin and hair findings 
David L. Smith, MD, J.Graham Smith, MD, Song W. Wong, MD, Richard D. deShazo, MD  Journal of Allergy and Clinical Immunology  Volume 95, Issue 1, Pages (January 1995) DOI: /S (95) Copyright © 1995 Mosby, Inc. Terms and Conditions

2 FIG. 1 Low-power hematoxylin-eosin–stained punch skin biopsy specimen. The epidermis shows mild hyperkeratosis and parakeratosis. The rete ridges are elongated. Journal of Allergy and Clinical Immunology  , DOI: ( /S (95) ) Copyright © 1995 Mosby, Inc. Terms and Conditions

3 FIG. 2 Volar aspect of elbow, showing ILC in our patient, C.C.
Journal of Allergy and Clinical Immunology  , DOI: ( /S (95) ) Copyright © 1995 Mosby, Inc. Terms and Conditions

4 FIG. 3 Trichorrhexis invaginata. On the left, the hair shaft is fractured. The right end shows typical “ball and socket” of TI; the distal portion of the shaft is invaginated into the proximal portion. Journal of Allergy and Clinical Immunology  , DOI: ( /S (95) ) Copyright © 1995 Mosby, Inc. Terms and Conditions

5 FIG. 4 Higher power magnification of “ball and socket.”
Journal of Allergy and Clinical Immunology  , DOI: ( /S (95) ) Copyright © 1995 Mosby, Inc. Terms and Conditions

6 FIG. 5 Appearance of scalp in patient C.C.
Journal of Allergy and Clinical Immunology  , DOI: ( /S (95) ) Copyright © 1995 Mosby, Inc. Terms and Conditions

7 FIG. 6 Improvement in skin after treatment with 12% ammonium lactate lotion in patient C.C. The eyebrows are sparse laterally, and the lips appear prominent. Journal of Allergy and Clinical Immunology  , DOI: ( /S (95) ) Copyright © 1995 Mosby, Inc. Terms and Conditions

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