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MicroRNA-21 and the Vulnerability of Atherosclerotic Plaques

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1 MicroRNA-21 and the Vulnerability of Atherosclerotic Plaques
Temo Barwari, Marieke Rienks, Manuel Mayr  Molecular Therapy  Volume 26, Issue 4, Pages (April 2018) DOI: /j.ymthe Copyright © 2018 The American Society of Gene and Cell Therapy Terms and Conditions

2 Figure 1 MicroRNA-21-Based Therapy for Plaque Vulnerability and In-Stent Restenosis Delivery of microRNA-21 (miR-21) mimic to atherosclerotic plaques by ultrasound-targeted microbubble destruction (UTMD) enhances smooth muscle cell proliferation while also steering monocytes toward a reparative, anti-inflammatory phenotype. Conversely, stents coated with miR-21 inhibitor (anti-miR-21) prevent in-stent restenosis through their anti-proliferative effect on smooth muscle cells. Molecular Therapy  , DOI: ( /j.ymthe ) Copyright © 2018 The American Society of Gene and Cell Therapy Terms and Conditions


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