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Serum 25-dihydroxyvitamin D levels correlate with CD4+Foxp3+ T-cell numbers in moderate/severe asthma  Emma S. Chambers, MSc, Alexandra M. Nanzer, MRCP,

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Presentation on theme: "Serum 25-dihydroxyvitamin D levels correlate with CD4+Foxp3+ T-cell numbers in moderate/severe asthma  Emma S. Chambers, MSc, Alexandra M. Nanzer, MRCP,"— Presentation transcript:

1 Serum 25-dihydroxyvitamin D levels correlate with CD4+Foxp3+ T-cell numbers in moderate/severe asthma  Emma S. Chambers, MSc, Alexandra M. Nanzer, MRCP, David F. Richards, MSc, Kimuli Ryanna, MRCP, Anna T. Freeman, MRCP, Peter M. Timms, FRCPath, Adrian R. Martineau, PhD, Christopher J. Griffiths, FRCGP, Christopher J. Corrigan, PhD, Catherine M. Hawrylowicz, PhD  Journal of Allergy and Clinical Immunology  Volume 130, Issue 2, Pages (August 2012) DOI: /j.jaci Copyright © 2012 American Academy of Allergy, Asthma & Immunology Terms and Conditions

2 Fig 1 SR asthmatic patients have a lower frequency of Foxp3+ Treg cells than do SS asthmatic patients, and serum 25(OH)D concentration correlates positively with Foxp3+ Treg cells in the peripheral blood. A, Representative dot plots demonstrating the gating strategy to define Treg cells. Values represent % of gated live CD4+CD3+ lymphocyte population. B, Frequency of Foxp3+ Treg cells in SS and SR asthmatic patients. Data shown as mean, 5%-95% CI, assessed by t test. C, Correlation of Foxp3+ Treg cells with serum 25(OH)D in all the patients with moderate to severe asthma. Assessed by Pearson correlation test. Journal of Allergy and Clinical Immunology  , DOI: ( /j.jaci ) Copyright © 2012 American Academy of Allergy, Asthma & Immunology Terms and Conditions

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