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Xiang-Yu Chen, Dieter Enders  Chem 

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Presentation on theme: "Xiang-Yu Chen, Dieter Enders  Chem "— Presentation transcript:

1 Multisubstituted Unnatural Prolines for Asymmetric Catalytic Domino Reactions 
Xiang-Yu Chen, Dieter Enders  Chem  Volume 4, Issue 1, Pages (January 2018) DOI: /j.chempr Copyright © 2017 Elsevier Inc. Terms and Conditions

2 Scheme 1 The Novel Asymmetric Organocatalytic Domino Reaction Employing a Catalytic System Based on Multisubstituted Unnatural Prolines (A) The multisubstituted-unnatural-proline derivative 1 catalyzed the domino reactions of ketones, nitroalkenes, and carboxylic acids. (B) Application of the new domino strategy for the asymmetric synthesis of (+)-pancracine. (C) Significant steps of the proposed reaction mechanism. Chem 2018 4, 21-23DOI: ( /j.chempr ) Copyright © 2017 Elsevier Inc. Terms and Conditions


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