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Life-Threatening Dextromethorphan Intoxication Associated with Interaction with Amitriptyline in a Poor CYP2D6 Metabolizer: A Single Case Re-Exposure.

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Presentation on theme: "Life-Threatening Dextromethorphan Intoxication Associated with Interaction with Amitriptyline in a Poor CYP2D6 Metabolizer: A Single Case Re-Exposure."— Presentation transcript:

1 Life-Threatening Dextromethorphan Intoxication Associated with Interaction with Amitriptyline in a Poor CYP2D6 Metabolizer: A Single Case Re-Exposure Study  Patrice Forget, MD, Bernard le Polain de Waroux, MD, Pierre Wallemacq, MD, PhD, Jean-Luc Gala, MD, PhD  Journal of Pain and Symptom Management  Volume 36, Issue 1, Pages (July 2008) DOI: /j.jpainsymman Copyright © 2008 U.S. Cancer Pain Relief Committee Terms and Conditions

2 Fig. 1 Plasma concentrations (ng/mL) of drugs. All concentrations remained stable except for dextromethorphan, which rapidly rose on Days 2 and 3. Journal of Pain and Symptom Management  , 92-96DOI: ( /j.jpainsymman ) Copyright © 2008 U.S. Cancer Pain Relief Committee Terms and Conditions


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