1. Scott Sibole, Ziad Abusara and Walter Herzog
Extending a Novel Technique for In Vivo Measurement of Chondrocyte Deformation to In Silico Biomechanics
Scott Sibole, Ziad Abusara and Walter Herzog
January 24, 2013
BMEN 613
Human Performance Laboratory, University of Calgary

2. Introduction Articular Cartilage Thin load bearing tissue Avascular
Very slow turnover
Millions of loading cycles
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3. Motivation Osteoarthritis Quality of life
Nearly 10% of US Population (Lawrence et al. Arthritis. Rheum., 2008.)
Adapted from Pritzker et al. Osteoarthritis and Cartilage, 2006.
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4. Problem Scope
Fair Use
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5. Previous Work Pioneer work at the University of Calgary BMEN 613 4/7
Abusara et al. Journal of Biomechanics, 2010.
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6. Objective To produce a computational model capable of simulating
the mechanics in the experiment.
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7. Method Bone Kinematics 3D Reconstruction Modeling and Simulation
Discretization
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8. Application Local mechanical environment Model validation
Courtesy of Mark van Turnhout, Eindhoven
Model validation
Material characterization
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