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Phillip J. Cozzi, B. S. , Ross T. Lyon, M. D. , Harry R. Davis, Ph. D

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Presentation on theme: "Phillip J. Cozzi, B. S. , Ross T. Lyon, M. D. , Harry R. Davis, Ph. D"— Presentation transcript:

1 Aortic wall metabolism in relation to susceptibility and resistance to experimental atherosclerosis 
Phillip J. Cozzi, B.S., Ross T. Lyon, M.D., Harry R. Davis, Ph.D., James Sylora, B.S., Seymour Glagov, M.D., Christopher K. Zarins, M.D.  Journal of Vascular Surgery  Volume 7, Issue 5, Pages (May 1988) DOI: / (88) Copyright © 1988 Society for Vascular Surgery and International Society for Cardiovascular Surgery, North American Chapter Terms and Conditions

2 Fig. 1 Schematic diagram of rabbit aorta with standardized sites from which tissue was taken for designated metabolic determinations. Deoxyglucose (DG), oxygen (O2), and lactic acid (LA), respectively, identify those segments from which tissue was taken for 2-deoxyglucose uptake, oxygen consumption, and lactic acid production determinations. Journal of Vascular Surgery 1988 7, DOI: ( / (88) ) Copyright © 1988 Society for Vascular Surgery and International Society for Cardiovascular Surgery, North American Chapter Terms and Conditions

3 Fig. 2 Index of cellularity in proximal (cross-hatched bars) and distal (solid bars) rabbit aortic wall for control and experimental groups. Asterisks signify statistical difference (p < 0.01) compared with normal control animals. Bars represent one standard deviation from the mean. Journal of Vascular Surgery 1988 7, DOI: ( / (88) ) Copyright © 1988 Society for Vascular Surgery and International Society for Cardiovascular Surgery, North American Chapter Terms and Conditions

4 Fig. 3 Radioautographs of proximal (A) and distal (B) aortic wall of a noncoarcted rabbit fed an atherogenic diet. Arrow indicates internal elastic lamina. A, Note foam cells in this section of atherosclerotic tissue proximal to the aortic wall containing black grains, indicating 14C-triply—labeled 2-deoxyglucose uptake, and relative lack of grains in the medial smooth muscle cells. Note the lack of nonspecific binding to extracellular matrix. B, Note the smooth muscle cells of the relatively thinner media of nonatherosclerotic distal aorta containing black grains indicative of 2-deoxyglucose uptake. (Hematoxylin counterstained; original magnification × 400.) Journal of Vascular Surgery 1988 7, DOI: ( / (88) ) Copyright © 1988 Society for Vascular Surgery and International Society for Cardiovascular Surgery, North American Chapter Terms and Conditions


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