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Viswanath P. Kurup, PhDa, Brian W. P

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1 Particulate Aspergillus fumigatus antigens elicit a TH2 response in BALB/c mice 
Viswanath P. Kurup, PhDa, Brian W.P. Seymour, MSb, Hongyung Choi, MDa, Robert L. Coffman, PhDb  Journal of Allergy and Clinical Immunology  Volume 93, Issue 6, Pages (June 1994) DOI: /S (94) Copyright © 1994 Mosby, Inc. Terms and Conditions

2 FIG. 1 Total serum IgE in nanograms per milliliter estimated by ELISA in the different groups of mice. All three groups of animals were exposed to Af soluble antigen intranasally, followed by one exposure to soluble Af (AF-SOL), antigen-coated beads (AF-Beads), or uncoated beads (Cont. Beads). IgE in normal control mice (Normal) is also given. Bar indicates standard error of the mean. Journal of Allergy and Clinical Immunology  , DOI: ( /S (94) ) Copyright © 1994 Mosby, Inc. Terms and Conditions

3 FIG. 2 Total serum IgG1 in micrograms per milliliter, estimated by ELISA, is given. All groups of animals are the same as in Fig. 1. Bar indicates standard error of the mean. Journal of Allergy and Clinical Immunology  , DOI: ( /S (94) ) Copyright © 1994 Mosby, Inc. Terms and Conditions

4 FIG. 3 Estimation of Af-specific IgG1 in nanograms per milliliter of serum. All groups of animals are the same as in Fig. 1. Bar indicates standard error of the mean. Journal of Allergy and Clinical Immunology  , DOI: ( /S (94) ) Copyright © 1994 Mosby, Inc. Terms and Conditions

5 FIG. 4 Peripheral blood eosinophils estimated on days 0, 2, 5, and 10 days after the final exposure of antigen in the different groups of mice. Details about the groups are given in the legend to Fig. 1. Bar indicates standard error of the mean. Fifth day (*) and tenth day ( +) eosinophil counts in the peripheral blood were significantly increased in the Af antigen–coated bead versus soluble antigen–exposed mice (p < 0.01). Journal of Allergy and Clinical Immunology  , DOI: ( /S (94) ) Copyright © 1994 Mosby, Inc. Terms and Conditions

6 FIG. 5 Section of the lung from a mouse exposed to polystyrene beads conjugated with Af antigen showing peribronchiolar and perivascular infiltrates containing numerous eosinophils. (Hematoxylin and eosin stain; ×400.) Journal of Allergy and Clinical Immunology  , DOI: ( /S (94) ) Copyright © 1994 Mosby, Inc. Terms and Conditions

7 FIG. 6 Section of the lung from animals exposed to soluble antigen showing very few eosinophils. (Hematoxylin and eosin stain; ×400.) Journal of Allergy and Clinical Immunology  , DOI: ( /S (94) ) Copyright © 1994 Mosby, Inc. Terms and Conditions

8 FIG. 7 Section of a lung from a normal mouse. (Hematoxylin and eosin stain; ×160.) Journal of Allergy and Clinical Immunology  , DOI: ( /S (94) ) Copyright © 1994 Mosby, Inc. Terms and Conditions


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