1. MK-591 acutely restores glomerular size selectivity and reduces proteinuria in human glomerulonephritis 
Antonio Guasch, M.D., Carlos F. Zayas, Kamal F. Badr, M.D. 
Kidney International 
Volume 56, Issue 1, Pages (July 1999)
DOI: /j x
Copyright © 1999 International Society of Nephrology Terms and Conditions

2. Figure 1 Structural formula of MK-591.
Kidney International  , DOI: ( /j x)
Copyright © 1999 International Society of Nephrology Terms and Conditions

3. Figure 2
The effects of treatment with MK-591 on albumin excretion rate (A) and IgG excretion rate (B) are shown. Mean values for protein excretion, pretreatment, and post-treatment are indicated separately by a solid circle with the vertical bar indicating theSEM.*P < 0.05.
Kidney International  , DOI: ( /j x)
Copyright © 1999 International Society of Nephrology Terms and Conditions

4. Figure 3
The fractional dextran clearances at baseline (▪) and after treatment with MK-591 (•) are shown. The dashed line (shown for comparison) indicates the fractional dextran clearance in 17 healthy individuals reported previously. *P < 0.05.
Kidney International  , DOI: ( /j x)
Copyright © 1999 International Society of Nephrology Terms and Conditions

5. Figure 4
Effects of treatment with MK-591 on glomerular membrane parameters and proteinuria: (A) main glomerular pores (ro), (B) shunt parameter (ωo), (C) fractional protein clearance via shunt (θ∞), (D) and the fractional clearances of albumin (○) and IgG (▵).*P < 0.05 vs. pretreatment.
Kidney International  , DOI: ( /j x)
Copyright © 1999 International Society of Nephrology Terms and Conditions