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Bactericidal activity and synergy studies of BAL9141, a novel pyrrolidinone-3- ylidenemethyl cephem, tested against streptococci, enterococci and methicillin-resistant.

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Presentation on theme: "Bactericidal activity and synergy studies of BAL9141, a novel pyrrolidinone-3- ylidenemethyl cephem, tested against streptococci, enterococci and methicillin-resistant."— Presentation transcript:

1 Bactericidal activity and synergy studies of BAL9141, a novel pyrrolidinone-3- ylidenemethyl cephem, tested against streptococci, enterococci and methicillin-resistant staphylococci  L.M. Deshpande, R.N. Jones  Clinical Microbiology and Infection  Volume 9, Issue 11, Pages (November 2003) DOI: /j x Copyright © 2003 European Society of Clinical Infectious Diseases Terms and Conditions

2 Figure 1 Time–kill curve for Streptococcus pneumoniae C (BAL9141 MIC, mg/L) using BAL9141 concentrations of 4, 8 and 16 mg/L. Clinical Microbiology and Infection 2003 9, DOI: ( /j x) Copyright © 2003 European Society of Clinical Infectious Diseases Terms and Conditions

3 Figure 2 Time–kill curve for Staphylococcus aureus 82-11A (BAL9141 MIC, 0.25 mg/L) using BAL9141 concentrations of 4, 8 and 16 mg/L. All concentrations achieved bactericidal action, but an ‘Eagle effect’ was detected. Clinical Microbiology and Infection 2003 9, DOI: ( /j x) Copyright © 2003 European Society of Clinical Infectious Diseases Terms and Conditions

4 Figure 3 BAL9141 synergy experiment with gentamicin (MIC/4) using E. faecium A (ampicillin and vancomycin susceptible). Clinical Microbiology and Infection 2003 9, DOI: ( /j x) Copyright © 2003 European Society of Clinical Infectious Diseases Terms and Conditions


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