1. Hodgkin’s lymphoma stage I/II Untreated, age 15-70
Favorable
CS I and II (max. 3 nodal areas) and <50years and MT ratio<0.35 and ESR<50 (no B symptoms) or ESR<30 (B symptoms present)
Unfavorable
CS II (≥ 4 nodal areas) or ≥50years or MT ratio≥0.35
or ESR≥50 (without B symptoms)
Randomization
Randomization
Standard (Any outcome of PET scan)
Experimental (According to PET scan)
Standard (Any outcome of PET scan)
Experimental (According to PET scan)
2 cycles ABVD + FDG-PET
(2nd period)
PET negative
PET positive
PET negative
PET positive
1 cycle ABVD + IN-RT 30Gy
2 cycles ABVD
2 cycles escalated BEACOPP + IN-RT 30Gy
2 cycles ABVD + IN-RT 30Gy
4 cycles ABVD
2 cycles escalated BEACOPP + IN-RT 30Gy
After amendment in 2010:
1 cycle ABVD + IN-RT 30Gy
1 cycle ABVD + IN-RT 30Gy
2 cycles escalated BEACOPP + IN-RT 30Gy
2 cycles ABVD + IN-RT 30Gy
2 cycles ABVD + IN-RT 30Gy
2 cycles escalated BEACOPP + IN-RT 30Gy