1. Localization and cellular function of spectraplakins.
Localization and cellular function of spectraplakins. Spectraplakins orchestrate various cytoskeletal interactions and mediate crosslinking in different cellular compartments. Therefore, they are able to regulate different cellular processes as illustrated here. 1, spectraplakins mediate the MT targeting of MTs to focal adhesions, which promotes focal adhesion turnover and cell motility; 2, spectraplakins have been shown to regulate the integrity of the nucleus, ER and the Golgi complex, as well as and vesicle transport; 3, spectraplakins also associate with adaptors such as ELMO proteins and mediate cytoskeletal crosslinking at the cortical membrane; 4, spectraplakins connect hemidesmosomes with IFs and strengthen the integrity of the basal layer.
Jamie Zhang et al. J Cell Sci 2017;130:
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