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Increased adhesion to vascular cell adhesion molecule-1 and intercellular adhesion molecule-1 of eosinophils from patients with asthma  Lena Håkansson,

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Presentation on theme: "Increased adhesion to vascular cell adhesion molecule-1 and intercellular adhesion molecule-1 of eosinophils from patients with asthma  Lena Håkansson,"— Presentation transcript:

1 Increased adhesion to vascular cell adhesion molecule-1 and intercellular adhesion molecule-1 of eosinophils from patients with asthma  Lena Håkansson, PhDa,c, Eythor Björnsson, MD, PhDb,c, Christer Janson, MD, PhDb,c, Birgitta Schmekel, MD, PhDc,d  Journal of Allergy and Clinical Immunology  Volume 96, Issue 6, Pages (December 1995) DOI: /S (95) Copyright © 1995 Mosby, Inc. Terms and Conditions

2 FIG. 1 Adhesion of eosinophil (A) and neutrophil (B) granulocytes from healthy individuals (n = 9), patients with allergic rhinitis (n = 10), patients with allergic asthma (n = 10), and patients with nonallergic asthma (n = 10) to E-selectin, VCAM-1, and ICAM-1. Results shown are median values and upper quartiles. Zero level represents background adhesion to native BHK fibroblasts. Journal of Allergy and Clinical Immunology  , DOI: ( /S (95) ) Copyright © 1995 Mosby, Inc. Terms and Conditions

3 FIG. 2 Adhesion of eosinophil (A) and neutrophil (B) granulocytes from healthy individuals (n = 9), patients with PEF variability of less than 10% (n = 12), and patients with PEF variability of more than 10% (n = 9) to E-selectin, VCAM-1, and ICAM-1. Results shown are median values and upper quartiles. Significances of difference among results of patients with >10% PEF variability, healthy individuals, and patients with <10% PEF variability, calculated by means of the Mann-Whitney U test, are indicated. Journal of Allergy and Clinical Immunology  , DOI: ( /S (95) ) Copyright © 1995 Mosby, Inc. Terms and Conditions

4 FIG. 3 Specific eosinophil (A) and neutrophil (B) cell surface expression of CD11b, CD18, and CD49d in healthy individuals (n = 9), patients with PEF variability of less than 10% (n = 12), and patients with PEF variability of more than 10% (n = 9). Results shown are median values and upper quartiles. Zero level represents background fluorescence (mean, 1.1 U; range, 1.0 to 1.66 U). Neutrophils do not express CD49d (mean, 0.0; range, 0.0 to 0.005). Journal of Allergy and Clinical Immunology  , DOI: ( /S (95) ) Copyright © 1995 Mosby, Inc. Terms and Conditions

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