Download presentation
Presentation is loading. Please wait.
1
Integrative physiology
Hemodynamics Volume balance osmotic balance Oxygen transport Acid-Base homeostasis
2
End diastolic pressere
Cardiac Output Frank-Starling law The heart is a pump driven by its inflow (or pressure on its input) End diastolic pressere
3
Basic properties of blood vessels
4
The heart is a pump driven by its inflow (or pressure on its input)
Inlet pressure Flow The heart is a pump driven by its inflow (or pressure on its input)
5
The heart is a pump driven by its inflow (or pressure on its input)
Elastic arteries Inlet pressure Flow Elastic veins The heart is a pump driven by its inflow (or pressure on its input) Capillary and arteriolar resistances
6
The heart is a pump driven by its inflow (or pressure on its input)
Elastic arteries Inlet pressure Flow Elastic veins The heart is a pump driven by its inflow (or pressure on its input) pressure Capillary and arteriolar resistances volume
7
The heart is a pump driven by its inflow (or pressure on its input)
Elastic arteries Inlet pressure Flow Elastic veins The heart is a pump driven by its inflow (or pressure on its input) pressure Capillary and arteriolar resistances volume
8
The heart is a pump driven by its inflow (or pressure on its input)
Elastic arteries Inlet pressure Flow Elastic veins The heart is a pump driven by its inflow (or pressure on its input) pressure Capillary and arteriolar resistances volume
9
The heart is a pump driven by its inflow (or pressure on its input)
Elastic arteries Inlet pressure Flow Elastic veins The heart is a pump driven by its inflow (or pressure on its input) pressure Capillary and arteriolar resistances volume
10
The heart is a pump driven by its inflow (or pressure on its input)
Elastic arteries Inlet pressure Flow Elastic veins The heart is a pump driven by its inflow (or pressure on its input) pressure Capillary and arteriolar resistances volume
11
The heart is a pump driven by its inflow (or pressure on its input)
Elastic arteries Inlet pressure Flow Elastic veins The heart is a pump driven by its inflow (or pressure on its input) pressure P Capillary and arteriolar resistances V volume V0 compliance C=dV/dP
12
The heart is a pump driven by its inflow (or pressure on its input)
Elastic arteries Inlet pressure Flow Elastic veins The heart is a pump driven by its inflow (or pressure on its input) pressure P Capillary and arteriolar resistances V volume V0 V0 compliance C=dV/dP
13
The heart is a pump driven by its inflow (or pressure on its input)
Elastic arteries Inlet pressure Flow Elastic veins The heart is a pump driven by its inflow (or pressure on its input) pressure P Capillary and arteriolar resistances V volume V0 compliance C=dV/dP
14
The heart is a pump driven by its inflow (or pressure on its input
Elastic arteries Inlet pressure Flow Elastic veins The heart is a pump driven by its inflow (or pressure on its input pressure P Capillary and arteriolar resistances V volume V0 compliance C=dV/dP
15
The heart is a pump driven by its inflow (or pressure on its input)
Elastic arteries Inlet pressure Flow Elastic veins The heart is a pump driven by its inflow (or pressure on its input) pressure P Capillary and arteriolar resistances V volume V0 compliance C=dV/dP
16
The heart is a pump driven by its inflow (or pressure on its input
Elastic arteries Inlet pressure Flow Elastic veins The heart is a pump driven by its inflow (or pressure on its input pressure P Capillary and arteriolar resistances C1 C2 V volume V0 compliance C=dV/dP
17
The heart is a pump driven by its inflow (or pressure on its input
Elastic arteries Inlet pressure Flow Elastic veins The heart is a pump driven by its inflow (or pressure on its input pressure P Capillary and arteriolar resistances C1 < C2 dV1 dV2 dP V volume V0 dV1/dP< dV2/dP compliance C=dV/dP
18
The heart is a pump driven by its inflow (or pressure on its input
Elastic arteries Inlet pressure Flow Elastic veins The heart is a pump driven by its inflow (or pressure on its input pressure P Capillary and arteriolar resistances C1 < C2 V volume V0 dV1/dP< dV2/dP compliance C=dV/dP
19
Guyton experiments
20
The heart is a pump driven by its inflow (or pressure on its input
Q Elastic arteries Elastic veins Pa The heart is a pump driven by its inflow (or pressure on its input Pv Capillary and arteriolar resistances
21
The heart is a pump driven by its inflow (or pressure on its input
Q=0 Elastic arteries Elastic veins Pa The heart is a pump driven by its inflow (or pressure on its input Pv Capillary and arteriolar resistances
22
The heart is a pump driven by its inflow (or pressure on its input
Q=0 Elastic arteries Elastic veins Pa The heart is a pump driven by its inflow (or pressure on its input Pv Capillary and arteriolar resistances
23
The heart is a pump driven by its inflow (or pressure on its input
Q=0 Elastic arteries Elastic veins Pa The heart is a pump driven by its inflow (or pressure on its input Pv Capillary and arteriolar resistances
24
Q=0 Pa = Pm Pv Elastic arteries Elastic veins Pv = Pa = Pm
Flow Q=0 Elastic arteries Elastic veins Pa = Pm Pv Pv = Pa = Pm Q Capillary and arteriolar resistances Pm Pm – „mean circulatory pressure“ Pv
25
Q Pa Pv Elastic arteries Elastic veins
Flow Q Elastic arteries Elastic veins Pa Pv Q Capillary and arteriolar resistances Pm Pv
26
Q Pa Pv Elastic arteries Elastic veins
Flow Q Elastic arteries Elastic veins Pa Pv Q Capillary and arteriolar resistances Pm Pv
27
Q Pa Pv Elastic arteries Elastic veins
Flow Q Elastic arteries Elastic veins Pa Pv Q Capillary and arteriolar resistances Pm Pv
28
Q Pa Pv Pv=0 Elastic arteries Elastic veins
Flow Q Elastic arteries Elastic veins Pa Pv Pv=0 Q Capillary and arteriolar resistances Pm Pv
29
Q cannot rise Pa Pv Pv<0 Elastic arteries Elastic veins
Flow Q cannot rise Elastic arteries Elastic veins Pv< 0 Pa Elastic veins collapses Pv Pv<0 Q Capillary and arteriolar resistances Pm Pv
30
Q=0 Pa = Pm Pv Pv= Pm Elastic arteries Elastic veins
Flow Q=0 Elastic arteries Elastic veins Pa = Pm Pv Pv= Pm Q Capillary and arteriolar resistances Pm Pv
31
Q Pa Pv Elastic arteries Elastic veins
Flow Q Elastic arteries Elastic veins Pa Pv Q Capillary and arteriolar resistances Pm Pv
32
Q Pa Pv Elastic arteries Elastic veins
Flow Q Flow Elastic arteries Elastic veins Pa Pv Q Capillary and arteriolar resistances Pm Pv
33
Q Pa Pv Elastic arteries Elastic veins
Flow Q Elastic arteries Elastic veins Pa Pv Q Capillary and arteriolar resistances Pm Pv
34
Q Pa Pv Elastic arteries Elastic veins
Flow Q Elastic arteries Elastic veins Pa Pv Q Capillary and arteriolar resistances Pm Pv
35
Q Pa Pv Pv=0 Elastic arteries Elastic veins
Flow Q Elastic arteries Elastic veins Pa Pv Pv=0 Q Capillary and arteriolar resistances Pm Pv
36
Q cannot rise Pa Pv Pv<0 Elastic arteries Elastic veins
Flow Q cannot rise Elastic arteries Elastic veins Pa Elastic veins collapes Pv Pv<0 Q Capillary and arteriolar resistances Pm Pv
37
Q=0 Pa = Pm Pv Pv= Pm Elastic arteries Elastic veins
Flow Q=0 Elastic arteries Elastic veins Pa = Pm Pv Pv= Pm Q Capillary and arteriolar resistances Pm Pv
38
Q=0 Pa = Pm Pv Pv= Pm Elastic arteries Elastic veins
Flow Q=0 Elastic arteries Elastic veins Pa = Pm Pv Pv= Pm Q Capillary and arteriolar resistances Pm Pv
39
Q Pa Pv Elastic arteries Elastic veins
Flow Q Elastic arteries Elastic veins Pa Pv Q Capillary and arteriolar resistances Pm Pv
40
Q Pa Pv Elastic arteries Elastic veins
Flow Q Flow Elastic arteries Elastic veins Pa Pv Q Capillary and arteriolar resistances Pm Pv
41
Q Pa Pv Elastic arteries Elastic veins
Flow Q Elastic arteries Elastic veins Pa Pv Q Capillary and arteriolar resistances Pm Pv
42
Q Pa Pv Elastic arteries Elastic veins
Flow Q Elastic arteries Elastic veins Pa Pv Q Capillary and arteriolar resistances Pm Pv
43
Q Pa Pv Pv=0 Elastic arteries Elastic veins
Flow Q Elastic arteries Elastic veins Pa Pv Pv=0 Q Capillary and arteriolar resistances Pm Pv
44
Q cannot rise Pa Pv Pv<0 Elastic arteries Elastic veins
Flow Q cannot rise Elastic arteries Elastic veins Pa Elastic veins collapes Pv Pv<0 Q Capillary and arteriolar resistances Pm Pv
45
Q=0 Pa = Pm Pv Pv= Pm Elastic arteries Elastic veins
Flow Q=0 Elastic arteries Elastic veins Pa = Pm Pv Pv= Pm Q Capillary and arteriolar resistances Pm Pv
46
Q=0 Pa = Pm Pv Pv= Pm Elastic arteries Elastic veins
Flow Q=0 Elastic arteries Elastic veins Pa = Pm Venotonus Pv Pv= Pm Q Capillary and arteriolar resistances Pm Pm Pv
47
Q=0 Pa = Pm Pv Pv= Pm Elastic arteries Elastic veins
Flow Q=0 Elastic arteries Elastic veins Pa = Pm Venotonus Pv Pv= Pm Blood Volume Q Capillary and arteriolar resistances Pm Pm Pv
48
Q=0 Pa = Pm Pv Pv= Pm Elastic arteries Elastic veins
Flow Q=0 Elastic arteries Elastic veins Pa = Pm Venotonus Pv Pv= Pm Blood Volume Q Capillary and arteriolar resistances Pm Pm Pv
49
Q Pa Pv Elastic arteries Elastic veins
Flow Q Elastic arteries Elastic veins Pa Venotonus Pv Blood Volume Q Capillary and arteriolar resistances Pm Pm Pv
50
Q Pa Pv Elastic arteries Elastic veins
Flow Q Flow Elastic arteries Elastic veins Pa Venotonus Pv Blood Volume Q Capillary and arteriolar resistances Pm Pm Pv
51
Q Pa Pv Elastic arteries Elastic veins
Flow Q Elastic arteries Elastic veins Pa Venotonus Pv Blood Volume Q Capillary and arteriolar resistances Pm Pm Pv
52
Q Pa Pv Elastic arteries Elastic veins
Flow Q Elastic arteries Elastic veins Pa Venotonus Pv Blood Volume Q Capillary and arteriolar resistances Pm Pm Pv
53
Q Pa Pv Pv=0 Elastic arteries Elastic veins
Flow Q Elastic arteries Elastic veins Pa Venotonus Pv Pv=0 Blood Volume Q Capillary and arteriolar resistances Pm Pm Pv
54
Q cannot rise Pa Pv Pv<0 Elastic arteries Elastic veins
Flow Q cannot rise Elastic arteries Elastic veins Pa Venotonus Elastic veins collapes Pv Pv<0 Blood Volume Q Capillary and arteriolar resistances Pm Pm Pv
55
Heart + Vessels
56
Cardiac output End diastolic pressure
57
End diastolic pressure
Cardiac output Increase of peripheral resistance End diastolic pressure
58
End diastolic pressure
Cardiac output Decrease of peripheral resistance Increase of peripheral resistance End diastolic pressure
59
or (increase of venotone)
Cardiac output Increase blood volume or (increase of venotone) Decrease of peripheral resistance Increase of peripheral resistance End diastolic pressure
60
or (increase of venotone) or (decrease of venotone)
Cardiac output Increase blood volume or (increase of venotone) Decrease of peripheral resistance Decrease blood volume or (decrease of venotone) Increase of peripheral resistance End diastolic pressure
61
End diastolic pressure
Cardiac output Frank-Starling curve Venous return curve End diastolic pressure
62
End diastolic pressure
Cardiac output Frank-Starling curve Venous return curve End diastolic pressure
63
End diastolic pressure
Cardiac output Frank-Starling curve Venous return curve End diastolic pressure
64
End diastolic pressure
Cardiac output Frank-Starling curve Venous return curve End diastolic pressure
65
End diastolic pressure
Cardiac output Frank-Starling curve Venous return curve End diastolic pressure
66
End diastolic pressure
Cardiac output Frank-Starling curve Venous return curve End diastolic pressure
67
End diastolic pressure
Cardiac output Frank-Starling curve Venous return curve End diastolic pressure
68
Cardiac output diuretics insufficiency kardiotonics Increasing the volume of circulating blood venokonstriction, vasoconstriction End diastolic pressure increase ! pulmonary edema, swelling End diastolic pressure
69
Starling curve and venous return curve
Cardiac output Starling curve Venous return curve preload Normal circulation 69
70
Starling curve and venous return curve
inotropy, heart rate preload Cardiac output Cardiac output inotropy, heart rate Starling curve Venous return curve preload Normal circulation Starling curve changes 70
71
Starling curve and venous return curve
inotropy, heart rate preload Cardiac output Cardiac output inotropy, heart rate Starling curve Venous return curve preload Normal circulation Starling curve changes Cardiac output resistance resistance preload Venous return curve changes 71
72
Starling curve and venous return curve
inotropy, heart rate preload Cardiac output Cardiac output inotropy, heart rate Starling curve Venous return curve preload Normal circulation Starling curve changes Cardiac output resistance Cardiac output venotonus, blood volume resistance venotonus, blood volume preload preload Venous return curve changes Venous return curve changes 72
73
Starling curve and venous return curve
inotropy, heart rate preload Cardiac output Cardiac output inotropy, heart rate Starling curve Venous return curve preload Normal circulation Starling curve changes Cardiac output resistance Cardiac output venotonus, blood volume resistance venotonus, blood volume preload preload Venous return curve changes Venous return curve changes 73
74
Basic Priciples of Hemodynamics in Shock
preload Cardiac output Starling curve Venous return curve Normal circulation 74
75
End diastolic pressure
Cardiac output Cardiac insufficiency Retention volume The increase in venous tone Vasoconstriction End diastolic pressure Cardiogenic shock preload 75
76
Basic Priciples of Hemodynamics in Shock
preload Cardiac output Cardiac output Starling curve inotropy resistance venotonus Venous return curve preload Normal circulation Cardiogenic shock 76
77
Cardiac output preload Increased heart rate and inotropy
Loss of volume Vasoconstriction Compensation - an increase of venous tone Hypovolemic shock preload 77
78
Basic Priciples of Hemodynamics in Shock
preload Cardiac output Cardiac output Starling curve inotropy resistance venotonus Venous return curve preload Normal circulation Cardiogenic shock blood volume resistance heart rate inotropy preload Hypovolemic shock 78
79
Cardiac output preload Increased heart rate and inotropy
cardiodepression vasodilatation Loss of volume – transsudation to ISF Distributive shock preload 79
80
Basic Priciples of Hemodynamics in Shock
preload Cardiac output Cardiac output preload Starling curve inotropy resistance venotonus Venous return curve Normal circulation Cardiogenic shock blood volume resistance resistance heart rate blood volume inotropy heart rate inotropy inotropy preload preload Hypovolemic shock Distributive shock 80
81
Basic Priciples of Hemodynamics in Shock
preload Cardiac output Cardiac output Starling curve inotropy resistance venotonus Venous return curve preload Normal circulation Cardiogenic shock 81
82
Basic Priciples of Hemodynamics in Shock
preload Cardiac output Cardiac output Starling curve inotropy resistance venotonus Venous return curve preload Normal circulation Cardiogenic shock blood volume resistance heart rate inotropy preload Hypovolemic shock 82
83
Basic Priciples of Hemodynamics in Shock
preload Cardiac output Cardiac output preload Starling curve inotropy resistance venotonus Venous return curve Normal circulation Cardiogenic shock blood volume resistance resistance heart rate blood volume inotropy heart rate inotropy inotropy preload preload Hypovolemic shock Distributive shock 83
84
Basic Priciples of Hemodynamics in Shock
preload Cardiac output Cardiac output preload Starling curve inotropy resistance venotonus Venous return curve Normal circulation Cardiogenic shock blood volume resistance resistance heart rate blood volume inotropy heart rate inotropy inotropy preload preload Hypovolemic shock Distributive shock 84
85
Oxygen delivery Circulation PiO2 PaO2 Hb SaO2 Ventilation CaO2*Q
86
Oxygen delivery Oxygen comsumption Circulation PiO2 PaO2 Hb SaO2
Ventilation CaO2*Q ATP/ADP ratio etc. Metabolic requirement VO2 Cells Oxygen comsumption
87
Oxygen delivery Oxygen comsumption Circulation PvO2 PaO2 Hb SaO2
Ventilation CaO2*Q CvO2 PaO2 Diffusion ATP/ADP ratio etc. PistO2 Metabolic requirement VO2 Cells Oxygen comsumption
88
Oxygen delivery Oxygen comsumption Circulation PiO2 PaO2 Hb SaO2
Ventilation CaO2*Q CvO2 PaO2 Diffusion ATP/ADP ratio etc. PistO2 Metabolic requirement VO2 VO2 criticalDO2 Cells Oxygen comsumption Oxygen delivery - DO2
Similar presentations
