1. 3 New subjects recruited for fMRI 3 PET Subjects lost to follow-up
Supplemental Figure 1 – Study Experimental Design
PET:
5-HT1A [11C]CUMI
3 New subjects recruited for fMRI
Healthy Subject
N = 13
Citalopram
Saline†
fMRI:
Emotional Faces Task
M = 2.4 years
(SD = 0.15)
Healthy Subjects
N = 13
(N = 10 with PET)
Citalopram‡
Saline‡
N = 10
3 PET Subjects lost to follow-up
> 1 week
† A total of N = 13 healthy subjects completed the two fMRI scans (i.e., after citalopram and saline infusions). Of the N = 13, ten subjects previously completed a PET 5-HT1A[11C]CUMI scan in which they received citalopram and saline. Only the dorsal raphe 5-HT1A[11C]CUMI BPND from the saline (placebo) infusion was used as a continuous predictor in the fMRI analysis of those 10 subjects.
‡ Citalopram and saline infusions were single-blinded, counterbalanced, and minimum of one week between scans.