1. Dietary regulation of apical GLUT2.
Dietary regulation of apical GLUT2. Wild-type mice were maintained on 50% complex sugar diet (“chow-fed”) or fructose-rich (65%) diet (“fructose-fed”). Some fructose-fed mice were fasted overnight before they received a gastric bolus of either PBS, glucose, fructose, glucose + fructose, or sucrose (“bolus”). Apical GLUT2 was very low in chow-fed or in fasted animals receiving a PBS bolus. The presence of GLUT2 was high in the apical membrane of animals fed ad libitum with the fructose-rich diet and in the apical membrane of mice receiving a bolus of simple sugar. Reproduced with permission (ref. 15).
George L. Kellett, and Edith Brot-Laroche Diabetes 2005;54:
©2005 by American Diabetes Association