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Long-term pathologic consequences of acute irritant-induced asthma

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Presentation on theme: "Long-term pathologic consequences of acute irritant-induced asthma"— Presentation transcript:

1 Long-term pathologic consequences of acute irritant-induced asthma
Naoya Takeda, MD, PhD, Karim Maghni, DSc, PhD, Sylvie Daigle, RN, Jocelyne L'Archevêque, RT, Lucero Castellanos, RT, Wisam Al- Ramli, BSc, Jean-Luc Malo, MD, Qutayba Hamid, MD, PhD  Journal of Allergy and Clinical Immunology  Volume 124, Issue 5, Pages e1 (November 2009) DOI: /j.jaci Copyright © 2009 American Academy of Allergy, Asthma & Immunology Terms and Conditions

2 Fig 1 Representative examples of hematoxylin and eosin staining in bronchial biopsies from healthy subjects (A) and subjects with RADS (B). Graph showing increased thickness of basement membrane (BM; C) and epithelial cell detachment (D) in bronchial biopsies from subjects with RADS compared with healthy control subjects and subjects with mild asthma. Absolute values for each subject are shown. Median values are indicated by horizontal scale bars. NS, not significant. Journal of Allergy and Clinical Immunology  , e1DOI: ( /j.jaci ) Copyright © 2009 American Academy of Allergy, Asthma & Immunology Terms and Conditions

3 Fig 2 Representative examples of immunostaining for TGF-β1 in bronchial biopsies from healthy subjects (A) and subjects with RADS (B). Arrows point to the positive staining in the subepithelial area. Graph shows the numbers of TGF-β1–positive cells per subepithelial area (mm2) in subjects with RADS compared with healthy controls and subjects with mild asthma (C). Journal of Allergy and Clinical Immunology  , e1DOI: ( /j.jaci ) Copyright © 2009 American Academy of Allergy, Asthma & Immunology Terms and Conditions

4 Fig 3 Representative examples of immunostaining for eosinophils in bronchial biopsies from healthy subjects (A) and subjects with RADS (B). Arrows point to the positive staining in the subepithelial area. Graph shows the numbers of ECP-positive cells (eosinophils) per subepithelial area (mm2) in subjects with RADS compared with healthy controls and subjects with mild asthma (C). Journal of Allergy and Clinical Immunology  , e1DOI: ( /j.jaci ) Copyright © 2009 American Academy of Allergy, Asthma & Immunology Terms and Conditions

5 Fig 4 Correlation between AHR and basement membrane thickness in subjects with RADS. Basement membrane (BM) thickness correlated with the value of PC20 at follow-up (n = 9; r = −0.783; P < .05). Journal of Allergy and Clinical Immunology  , e1DOI: ( /j.jaci ) Copyright © 2009 American Academy of Allergy, Asthma & Immunology Terms and Conditions

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