1. Sphingosine 1-phosphate protects ovaries from chemotherapy-induced damage in vivo 
Katharina Hancke, M.D., Oliver Strauch, V.M.D., Christine Kissel, M.D., Heike Göbel, M.D., Wolfgang Schäfer, Ph.D., Dominik Denschlag, M.D. 
Fertility and Sterility 
Volume 87, Issue 1, Pages (January 2007)
DOI: /j.fertnstert
Copyright © 2007 American Society for Reproductive Medicine Terms and Conditions

2. FIGURE 1 Metabolic pathways of S1P formation.
Hancke. S1P protects ovaries from chemotherapy-induced damage. Fertil Steril 2007.
Fertility and Sterility  , DOI: ( /j.fertnstert )
Copyright © 2007 American Society for Reproductive Medicine Terms and Conditions

3. FIGURE 2
Trial profile.
Hancke. S1P protects ovaries from chemotherapy-induced damage. Fertil Steril 2007.
Fertility and Sterility  , DOI: ( /j.fertnstert )
Copyright © 2007 American Society for Reproductive Medicine Terms and Conditions

4. FIGURE 3
(A and B) Ovarian tissue with viable follicles at different developmental stages in group A2 (upper part), in contrast to areas of fibrotic stromal tissue in group A1 (lower part) (magnification ×400).
Hancke. S1P protects ovaries from chemotherapy-induced damage. Fertil Steril 2007.
Fertility and Sterility  , DOI: ( /j.fertnstert )
Copyright © 2007 American Society for Reproductive Medicine Terms and Conditions

5. FIGURE 4
Number of nonatretic follicles per field of view depending on the treatment (mean ± SEM);  group C (no chemo),  group B (PET), group A1 (0.5 mM S1P),  group A2 (2 mM S1P); ☆ statistically significant compared with group B and A1.
Hancke. S1P protects ovaries from chemotherapy-induced damage. Fertil Steril 2007.
Fertility and Sterility  , DOI: ( /j.fertnstert )
Copyright © 2007 American Society for Reproductive Medicine Terms and Conditions