1. Schematic summary of ROS signaling on coronary artery malformation in the offspring of pregestational diabetic mice.
Schematic summary of ROS signaling on coronary artery malformation in the offspring of pregestational diabetic mice. Pregestational diabetes increases ROS through hyperglycemia. ROS production inhibits HIF-1α and Wt1 expression in the fetal heart. Downregulation of Wt1 decreases epicardial EMT and results in coronary artery malformation through inhibition of Snail/Slug and RALDH2/bFGF pathways. All these abnormalities were prevented by treatment with NAC in the diabetic dams.
Hoda Moazzen et al. Diabetes 2015;64:
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