1. Sticking It to Cancer with Molecular Glue for SHP2
Hao Ran, Ryouhei Tsutsumi, Toshiyuki Araki, Benjamin G. Neel 
Cancer Cell 
Volume 30, Issue 2, Pages (August 2016)
DOI: /j.ccell
Copyright © 2016 Elsevier Inc. Terms and Conditions

2. Figure 1
Schematics Illustrating Key Features of SHP2 Regulation and Function
(A) SHP2 switches from a closed (inactive) to an open (active) form upon binding to specific phosphotyrosyl peptide motifs in RTKs/scaffold proteins.
(B) Role of SHP2 in growth factor/cytokine-dependent RAS/ERK pathway activation (left) and in mediating the inhibitory function of PD-1 (and other immune-inhibitory receptors) on TCR signaling (right).
(C and D) Effects of active site-targeting inhibitor (C) or allosteric inhibitor SHP099 (D) on SHP2.
Cancer Cell  , DOI: ( /j.ccell )
Copyright © 2016 Elsevier Inc. Terms and Conditions