1. Intrapatient variability in cyclosporine blood levels in renal transplant patients.
Intrapatient variability in cyclosporine blood levels in renal transplant patients. The x axis represents various time points after the cyclosporine dose when the cyclosporine level was measured. The y axis represents the whole-blood cyclosporine level. The lines in red highlight two patients with similar trough levels but very different peak concentrations. Early after transplantation, the patient with a low Cmax would be at a higher risk for acute rejection, whereas the patient with a high Cmax would be at risk for cyclosporine toxicity. In neither case would C0 monitoring identify which patient was at risk. Adapted from Levy (56).
Jeffrey Schiff et al. CJASN 2007;2:
©2007 by American Society of Nephrology