1. Zn2+ and NAD(P)H content in Mafa∆panc and Mafa∆panc;Mafb+/− β-cells.
Zn2+ and NAD(P)H content in Mafa∆panc and Mafa∆panc;Mafb+/− β-cells. (A) Total islet Zn+2 content was reduced to 56% in 3-month-old Mafa∆panc islets and 37% in Mafa∆panc;Mafb+/− islets (wild-type, n = 10; Mafa∆panc, n = 9; Mafa∆panc;Mafb+/−, n = 5). *P < 0.05; **P < (B) Normalized glucose dose-response curve of NAD(P)H levels in 3-month-old wild-type, Mafa∆panc, and Mafa∆panc;Mafb+/− islets (n = 4). The NAD(P)H response was not significantly different from base line until 20 mmol/L glucose. *P < 0.05, independent samples. arb., arbitrary.
Yan Hang et al. Diabetes 2014;63:
©2014 by American Diabetes Association